Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner.

Objective: Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias of the output parameters obtained by a detailed analysis of the time activity curves (TACs). The DTC method currently used for the Siemens 3T MR BrainPET insert is global, i.

A detector block-pairwise dead time correction method for improved quantitation with a dedicated BrainPET scanner.

'. Dead time correction (DTC) is an important factor in ensuring accurate quantification in PET measurements. This is currently often achieved using a global DTC method, i.