Stereotactic radiosurgery for brain metastases from extra-renal clear cell carcinoma: A series of four patients and review of the literature.

Background: Clear cell carcinoma occurring outside of the kidney represents an aggressive histological subtype which is frequently resistant to standard chemotherapy. Brain metastases (BM) from extra-renal clear cell carcinoma (erCCC) are exceedingly rare, and the optimal treatment approach for this histology remains uncertain. To our knowledge, stereotactic radiosurgery (SRS) has not been specifically investigated for this patient population.

Adenoid cystic carcinoma brain metastases treated with stereotactic radiosurgery: A single institution retrospective cohort study and comprehensive literature review.

Adenoid cystic carcinoma (ACC) is a malignant neoplasm arising from the minor and major salivary glands that tend to spread by perivascular and perineural routes. Brain metastases (BM) secondary to ACC are extremely rare, and the standard management strategy has not been well reported due to the rarity. Notably, no previous study has specifically examined the efficacy of stereotactic radiosurgery (SRS) for BM from ACC.

Exoscope-Assisted Spine Surgery: A Systematic Review From Basic to Complex Pathologies.

Operative neurosurgery has greatly benefited from technological advancements over the past several decades. However, challenges such as limited visualization, intraoperative navigation difficulties, and the complexity of spinal anatomy continue to pose significant hurdles for surgeons. The utilization of advanced technologies, such as exoscopes, navigation systems, and robotics, can help overcome some of these challenges, thereby enhancing surgical precision and accuracy.

Comparative Analysis Between Cortical Bone Trajectory (CBT) Screw Fixation and Traditional Pedicle Screw Fixation in Lumbar Spine Surgery: A Systematic Review and Meta-Analysis.

Cortical bone trajectory (CBT) screw fixation has been proposed as an alternative method to pedicle screw (PS) fixation for lumbar instrumented fusion. However, the benefits of this technique remain controversial. We searched PubMed, Scopus, Web of Science Advance, ScienceDirect, Embase (Ovid), and Cochrane databases from inception to July 22, 2023.

Overview of Preclinical and Clinical Trials of Nanoparticles for the Treatment of Brain Metastases.

Brain metastases (BM), which most commonly originate from lung, breast, or skin cancers, remain a major clinical challenge, with standard treatments such as stereotactic radiosurgery (SRS), surgical resection, and whole-brain radiation therapy (WBRT). The prognosis for patients with BM remains poor, with a median overall survival (OS) of just 10-16 months. Although recent advances in systemic therapies, including small molecule inhibitors, monoclonal antibodies, chemotherapeutics, and gene therapies, have demonstrated success in other malignancies, their effectiveness in central nervous system (CNS) cancers is significantly limited by poor blood-brain barrier (BBB) permeability and subtherapeutic drug concentrations in the brain.

Stereotactic Radiosurgery and Surgical Resection for Jugular Foramen Schwannomas: A Retrospective Comparative Study of Outcomes.

Background And Objectives: Jugular foramen schwannomas (JFS) are rare benign tumors arising from lower cranial nerves. In this study, we aim to compare the outcomes of surgical resection (SR) and stereotactic radiosurgery (SRS) in the treatment of JFS.

Methods: We conducted a retrospective analysis of 31 patients with JFS who underwent SRS (13 patients [41.

Local tumor control and neurological outcomes after surgery for spinal hemangioblastomas in sporadic and von Hippel-Lindau disease: A multicenter study.

Background: Spinal hemangioblastomas (sHBs) are rare vascular tumors with significant neurological implications. Their management, particularly in von Hippel-Lindau (VHL) disease, remains challenging due to recurrence and functional decline. Timely identification and intervention are critical for optimal outcomes.