Asciminib stands out as the superior tyrosine kinase inhibitor to combine with anti-CD20 monoclonal antibodies for the treatment of CD20 Philadelphia-positive B-cell precursor acute lymphoblastic leukemia in preclinical models.

Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL) is a high-risk subtype of acute lymphoblastic leukemia characterized by the presence of the BCR::ABL1 fusion gene. Tyrosine kinase inhibitors (TKI) combined with chemotherapy are established as the first-line treatment. Additionally, rituximab, an anti-CD20 monoclonal antibody is administered to adult BCP-ALL patients with ≥20% CD20+ blasts.

Advancements in cancer immunotherapies targeting CD20: from pioneering monoclonal antibodies to chimeric antigen receptor-modified T cells.

CD20 located predominantly on the B cells plays a crucial role in their development, differentiation, and activation, and serves as a key therapeutic target for the treatment of B-cell malignancies. The breakthrough of monoclonal antibodies directed against CD20, notably exemplified by rituximab, revolutionized the prognosis of B-cell malignancies. Rituximab, approved across various hematological malignancies, marked a paradigm shift in cancer treatment.

Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors.

Breakpoint cluster region-Abelson () gene fusion is an essential oncogene in both chronic myeloid leukemia (CML) and Philadelphia-positive (Ph) B-cell acute lymphoblastic leukemia (B-ALL). While tyrosine kinase inhibitors (TKIs) are effective in up to 95% of CML patients, 50% of Ph B-ALL cases do not respond to treatment or relapse. This calls for new therapeutic approaches for Ph B-ALL.

[Expectations towards forensic professionals conducting external examinations of dead bodies on the crime scene--results of a questionnaire distributed among public prosecutors in the Mazovian Voivodeship].

Unlabelled: The purpose of this study was to determine expectations of public prosecutors towards forensic professionals participating in external examinations of dead bodies performed at the site of finding the corpses. The presence of forensic physicians on the crime scene was recognized as advantageous by all prosecutors; however, expectations associated with corpse inspection did not correspond to capabilities of modern medicine or necessitated repeating activities performed during autopsies. Homicides (99%), deaths of children (86%) and "media" deaths (73%) were indicated as cases when the presence of forensic professional was especially important.

[The effect of alcohol consumption on the severity of injuries, prognosis and mortality--a review of literature].

The paper is a review of the most current academic literature published in the English language and addressing the effect of alcohol consumption on the severity of injuries, prognosis and mortality with special emphasis placed on the consultative usefulness of such publications. The report was inspired by repeated questions asked in association with expert opinions on the effects of injuries and addressing a possible effect of alcohol consumption by the victims on the severity of injuries and prognosis. In case of such questions, a valuable supplement to an opinion based on on the expert's professional experience may be found in an analysis of publications focusing on the subject.

[Atypical form of the Simon's symptom in the case of accidental hanging of an 11-year-old boy].

The repot describes a case of death of an 11-year old boy who died due to fatal accidental hanging from a noose at the attic floor.

[Death of a 57-year old male with previously undiagnosed displacement of the abdominal organs to the chest].

The report describes a death of a 57-year old male who died due to exacerbated cardiac and pulmonary insufficiency caused by the displacement of the abdominal organs to the chest through a previously undiagnosed diaphragmatic hernia.