Neuronal Waveform Classification in Multielectrode Recordings Using Machine Learning Techniques and Multidimensional Analysis.

Extracellular recordings of neuronal spikes are crucial for studying brain activity. These signals are typically classified based on firing patterns and waveform shape, particularly trough-to-peak duration. While useful, this method oversimplifies the diversity of cortical neurons and discharge patterns.

Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.

Optogenetics has transformed the study of neural circuit function, but limitations in its application to species with large brains, such as non-human primates (NHPs), remain. A major challenge in NHP optogenetics is delivering light to sufficiently large volumes of deep neural tissue with high spatiotemporal precision, without simultaneously affecting superficial tissue. To overcome these limitations, we recently developed and tested in NHP cortex, the Utah Optrode Array (UOA).

New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4.

PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down-regulation of degradation of the tumor suppressor gene p53. Given the relationship between both PADI4 and MDM2 with p53-signaling pathways, we hypothesized they may interact directly, and this interaction could be relevant in the context of cancer.