FTIR-based profiling of sinusitis: Stabilized feature selection through Boruta and Monte Carlo methods.

Sinusitis is a prevalent inflammatory condition lacking rapid, non-invasive diagnostic tools. In this study, Fourier-transform infrared (FTIR) spectroscopy was applied to distinguish serum samples collected from sinusitis patients and healthy controls. FTIR spectra were preprocessed and analyzed using a robust, two-stage feature selection framework combining the Boruta algorithm and Monte Carlo Feature Selection within a nested cross-validation design.

Anterolateral thigh free flap in reconstruction of lateral skull base defects after oncological resection.

Purpose: Evaluation of the utility of the free anterolateral thigh flap reconstruction of the defects resulting from radical temporal bone resection in the management of lateral skull base malignancies in a single institution.

Methods: An analysis of 17 en bloc subtotal petrosectomies for removal of malignant tumours was performed. There were 12 squamous cell carcinomas, 4 basal cell carcinomas and 1 adenoid cystic carcinoma.

Expression of selected regulatory molecules on the CD83+ monocyte-derived dendritic cells generated from patients with laryngeal cancer and their clinical significance.

B7H1 and B7H4 overexpression is associated with inhibition of the immune system in many solid tumors, and altogether with CD200 molecule plays an important role in tumor invasion by promoting malignant transformation. However, there is no report about impact of these molecules on laryngeal squamous cell carcinoma. The objective of the present study was to assess by means of flow cytometry the expression of B7H1, B7H4, CD200, and CD200R on CD83+ monocyte-derived dendritic cells (Mo-DC), pulsed with autologous tumor cell lysates (aTCL) in patients who suffer from G1, G2, or G3 laryngeal carcinoma (LC, n = 60) in comparison to healthy donors (HD, n = 15).

[Complications of surgical treatment in patients with laryngeal and hypopharyngeal cancer].

Introduction: Surgical treatment of patients with laryngeal or/and hypopharyngeal cancer is combined with potential risk of complications either local and general. The aim of the study was to evaluate the occurrence of them in the large cohort of patients with mentioned localization of cancer.

Material And Methods: The group of 447 patients, treated between 2000-2005 in Department of Otolaryngology and Laryngological Oncology, Medical University of Lublin were analyzed retrospectively.

[Importance of donor site vascular imaging in free fibula flap reconstruction].

Introduction: Free fibula flap is widely used in head and neck reconstruction. Imaging studies of the donor site can reveal vascular abnormalities and therefore prevent acute leg ischemia.

Aim: Evaluation of the role of donor site vascular imaging studies for free fibula flap planing.

[The assessment of selected molecules belonging to B7 family on the mature dendritic cells in laryngeal cancer patients].

Unlabelled: B7-H1, B7-H2 and B7-H4 molecules play various roles in the adaptive immune system and are broadly expressed on many cells, especially those localized in cancer tissue. The aim of the study was to assess the surface expression of B7-H1, B7-H2 and B7-H4 molecules on the mature dendritic cells (DC) generated from peripheral blood monocytes of laryngeal cancer patients and healthy donors.

Material And Methods: Forty-four male patients treated surgically for squamous cell carcinoma of the larynx were included in the study.

[Evaluation of cytochrome concentration in peripheral blood lymphocytes of patients with laryngeal cancer].

The aim of the study was evaluation of cytochrome concentration in the peripheral blood lymphocytes of patients with laryngeal cancer. The study was conducted in a group of 62 patients presenting different clinical advancement of the disease. The study material consisted of the studied population's peripheral blood from which T lymphocytes were isolated and incubated with monoclonal antibodies.