Evaluation of Self-Assembled Nanofibrous Aggregates (SNAs) for Assessing Osteogenic Potential in the Development of Bioinks for Bone Tissue Regeneration.

A long-standing challenge in regenerative medicine is replicating the extracellular matrix (ECM) of bone. Polyelectrolyte complexes (PECs) have been widely studied in tissue engineering; however, their potential in forming nanofibrous architectures that closely resemble the ECM of bone remains unexplored. This study evaluates the potential of self-assembled nanofibrous aggregates (SNAs) in developing bioinks for facilitating bone repair and growth using bone marrow mesenchymal stem cells (BM-MSCs).