AlphaBind, a domain-specific model to predict and optimize antibody-antigen binding affinity.

Antibodies are versatile therapeutic molecules that use combinatorial sequence diversity to cover a vast fitness landscape. Designing optimal antibody sequences, however, remains a major challenge. Recent advances in deep learning provide opportunities to address this challenge by learning sequence-function relationships to accurately predict fitness landscapes.

Flexor Carpi Radialis Tendon Stabilization for Chronic First Carpometacarpal Joint Instability: Clinical Outcomes from a Case Report.

Introduction: Chronic instability of the carpometacarpal (CMC) joint of the thumb can significantly impair hand function and cause persistent pain. Stabilising this joint is crucial for restoring function and alleviating discomfort. Utilising the flexor carpi radialis (FCR) tendon for stabilisation has shown promise due to its anatomical suitability and biomechanical properties.