Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.

Unlabelled: Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling . In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also suppresses inflammation, liver steatosis, neurodegeneration, and lethality . Defects in autophagy contribute to metabolic, inflammatory and degenerative diseases, however, the specific mechanisms involved were unclear .

Importance of medical home domains on emergency visits using a cross-sectional national survey of US children.

Background And Objectives: Receiving care at patient-centred medical homes (PCMH) is associated with reduced emergency department (ED) visits among children. Adverse social determinants of health (SDoH), such as lower socioeconomic status and household poverty, are associated with increased ED visits in children. The objective of this study is to use machine learning techniques to understand the relative importance of each PCMH component among different populations with adverse SDoH on the outcome of ED visits.

Clusters of long COVID among patients hospitalized for COVID-19 in New York City.

Background: Recent studies have demonstrated that individuals hospitalized due to COVID-19 can be affected by "long-COVID" symptoms for as long as one year after discharge.

Objectives: Our study objective is to identify data-driven clusters of patients using a novel, unsupervised machine learning technique.

Methods: The study uses data from 437 patients hospitalized in New York City between March 3rd and May 15th of 2020.

Resident pre-dictation of ED case delay signoff of those reports, but overall, residents improve report turnaround time.

Purpose: In academic radiology departments, attendings and resident are increasingly working together overnight for Emergency Department (ED) radiology coverage. The purpose of this study was to quantify reporting turnaround time for overnight cases read by residents and for overnight shifts with residents on duty.

Methods: A retrospective study was performed at a hospital system where one overnight attending covers two hospitals with a 2nd/3rd year overnight resident, and a second overnight attending covers two other hospitals 80% of the time independently and 20% of the time with a fourth-year resident.