Antimicrobial resistance (AMR) poses a significant threat to global health security, and Saudi Arabia plays a key role in addressing this challenge. This review highlights Saudi Arabia's National Action Plan, which focuses on improving data collection, monitoring AMR trends, and promoting the responsible use of antimicrobials in human and veterinary medicine. While the Kingdom has shown leadership in regional AMR control efforts, recent data indicate rising resistance rates among key pathogens, including methicillin-resistant Staphylococcus aureus and carbapenem-resistant Klebsiella pneumoniae, posing a growing public health concern.
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