EXPRESS: Methylation levels of the LEP, LEPR, and ADIPOQ genes and their association with metabolically healthy obesity.

It has been reported that DNA methylation in the epigenetic profile of the genes LEP and ADIPOQ is associated with obesity. To the best of our knowledge, there are no previous reports assessing the methylation of the LEP, LEPR, and ADIPOQ genes in subjects with metabolically healthy obesity (MHO). Therefore, the aim of this study was to determine the association between methylation of the LEP, LEPR, and ADIPOQ genes with the MHO phenotype.

Differential methylation of and genes associated with Parkinson's disease in Mexican Mestizos.

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (individuals of mixed Indigenous and European-primarily Spanish-ancestry who represent the majority demographic in Mexico) remain limited. DNA methylation may play a role in PD pathogenesis, with peripheral blood methylation patterns serving as potential biomarkers.

α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson's disease in Mexican Mestizos.

Clinical criteria diagnose Parkinson's disease (PD), therefore, it is crucial to find biological elements that could support diagnosis or even act as prognostic tools of PD. The SNCA gene codifies a protein called α - synuclein; several studies associate genetic and biochemical factors of SNCA with PD, including transcript and plasmatic protein levels, however, contradictory evidence indicates inconclusive results. We aim to compare SNCA mRNA expression, plasmatic α-syn protein and rs356219 SNP between PD cases and a control group, and to identify a potential biomarker in Mexican mestizos', focusing on these three components determined in blood.

infection in people in the city of Durango, Mexico: a cross sectional study.

Objective: To determine the seroprevalence of immunoglobulin (Ig)G and IgM antibodies and its association with the characteristics of the study population from the northern Mexican city of Durango, Mexico.

Methods: Through a cross-sectional study design, inhabitants of Durango City, Mexico were surveyed between June 2018 and November 2018. Serum samples from the subjects were analysed for anti- IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays.

Toxoplasma gondii infection and multiple sclerosis: An age- and a gender-matched case-control seroprevalence study.

The link between Toxoplasma gondii infection and multiple sclerosis remains controversial. In the present study, we aimed to determine the association between T. gondii seropositivity and multiple sclerosis.

Prevalence of Infection Diagnosed by Polymerase Chain Reaction in Female Sex Workers in a Northern Mexican City.

Purpose: We aimed to determine the association between infection and female sex work, and the association between sociodemographic, obstetric, and behavioral characteristics of female sex workers and infection.

Methods: Through a case-control study design, we studied 201 female sex workers and 201 age-matched women without sex work in Durango City, Mexico. DNA was detected in cervical swab samples using polymerase chain reaction.

Human Papillomavirus Infection in Female Sex Workers: A Case Control Study.

Background: To determine the association of infection with human papillomavirus (HPV) and the occupation of female sex worker; and the correlation of infection with HPV with sociodemographic, clinical and behavioral characteristics of female sex workers.

Methods: We performed a case-control study of 217 female sex workers and 354 women without sex work in Durango City, Mexico. We determined the prevalence of infection with HPV in cervical samples of women using polymerase chain reaction, and HPV genotypes were determined using line probe assay.

Lack of Association Between Cytomegalovirus Infection and Hypertensive Disorders in Pregnancy: A Case-Control Study in Durango, Mexico.

It is not clear whether infection with cytomegalovirus (CMV) is associated with hypertensive disorders in pregnant women. Through a case-control study design, 146 women suffering from hypertensive disorders in pregnancy (cases) and 146 age-matched normotensive pregnant women (controls) were examined for the presence of anti-CMV IgG and IgM antibodies with enzyme-linked immunoassays. IgM seropositive samples were further assayed by enzyme-linked fluorescent assay (ELFA).

Lack of Association between Mannose-binding Lectin 2 Codons 54 and 57 Gene Polymorphisms and Cervicovaginal Infections in Mexican Women.

The mannose-binding lectin (MBL) 2 gene has an important function in the innate immune response and activation of the third pathway of the complement system. Some studies have assessed the association of the MBL2 gene polymorphisms with cervicovaginal infections (CVI); however, there is no information about this association in Mexican women. This study aimed to determine the association between the MBL2 codons 54 and 57 gene polymorphisms with CVI in a sample of Mexican women.

Concordance of Infection Markers Among Heterosexual Couples.

Background: Very little is known about concordance of () infection markers among couples. Through a cross-sectional study, we sought to determine the correlation of infection in a sample of 119 heterosexual couples in Durango State, Mexico.

Methods: Participants were examined for the presence of anti- IgG and IgM antibodies using enzyme-linked immunoassays.

Lack of Association Between Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population.

Background: Very little is known about the association between infection with Toxoplasma gondii () and diabetes mellitus. We perform an age- and gender-matched case-control study to determine the association of infection and diabetes mellitus.

Methods: Cases included 156 patients with diabetes mellitus and 156 controls without diabetes mellitus who attended in two public clinics in Durango City, Mexico.

Lack of association between Toxoplasma gondii exposure and depression in pregnant women: a case-control study.

Background: Very little is known about the link of T. gondii infection and depression. Through an age-, gender-, and month of pregnancy-matched case-control study, we determined the association of T.

exposure and Parkinson's disease: a case-control study.

Objectives: To determine the association between infection and Parkinson's disease and to investigate whether seropositivity is associated with the general characteristics of patients with Parkinson's disease.

Design: Case-control study.

Setting: Cases and controls were enrolled in Durango City, Mexico.

Influence of Infection on Symptoms and Signs of Premenstrual Syndrome: A Cross-sectional Study.

Infection with in brain may cause some symptoms that resemble those in women with premenstrual syndrome. To determine the association of . infection with symptoms and signs of premenstrual syndrome, we examined 489 women aged 30-40 years old.

High Prevalence of Infection in Miners: A Case-Control Study in Rural Durango, Mexico.

Background: Very little is known about the seroepidemiology of infection with the parasite in miners. We determine the association of infection and the occupation of miner, and the association of seropositivity for with the socio-demographic, clinical, work and behavioral characteristics of the miners.

Methods: Through a case-control study, 125 miners working in Durango State, Mexico and 250 age- and gender-matched non-miner subjects were examined for the presence of anti- IgG and IgM antibodies using enzyme-linked immunoassays.

Toxoplasma gondii Infection and Premenstrual Dysphoric Disorder: A Cross-Sectional Study.

Background: Premenstrual dysphoric disorder is a severe form of premenstrual syndrome. The influence of Toxoplasma gondii (T. gondii) infection on clinical features in women with this disorder has not been studied.

Oxidative stress equilibrium during obstetric event in normal pregnancy.

Objective: The aim of this study was to determine malondialdehyde (MDA) concentration as an oxidative stress marker and total antioxidant capacity (TAC) in pregnancy before and after perinatal event.

Methods: This study was performed on 200 healthy full-term pregnant women admitted to pregnancy resolution in Maternal-Child Hospital of Durango, Mexico. Oxidative stress and TAC were assessed through detection of lipid peroxidation by quantitation of thiobarbituric acid-reactive substances (TBARS) and TAC through ferric reducing ability of the plasma (FRAP).

Rubella Immune Status in Pregnant Women in a Northern Mexican City.

Background: The seroepidemiology of rubella virus infection in pregnant women in northern Mexico is largely unknown. We sought to determine the seroprevalence of rubella virus infection in pregnant women in the northern Mexican city of Durango, Mexico. Seroprevalence association with the socio-demographic, clinical and behavioral characteristics of the pregnant women was also investigated.

Lack of association between Toxoplasma gondii infection and hypertensive disorders in pregnancy: a case-control study in a Northern Mexican population.

Background: The outcome of pregnancy is often threatened by hypertension disorders, i.e. eclampsia.

Association of COMT G675A and MTHFR C677T polymorphisms with hypertensive disorders of pregnancy in Mexican mestizo population.

Objective: To investigate the relationship between COMT G675A and MTHFR C677T polymorphisms and hypertension disorders of pregnancy (HDP) in a Mexican mestizo population.

Design And Methods: This case-control study involved 194 HDP and 194 normoevolutive pregnant women. The polymorphisms were genotyped by real time PCR.

Haplotype analysis of TGF-β1 gene in a preeclamptic population of northern Mexico.

Objective: To determine the frequencies of -800G/A (rs1800468), -509C/T (rs1800469) and 869T/C (rs1800470) polymorphisms and their haplotypes in the TGF-β1 gene and their association with preeclampsia in a population of northern México.

Design And Methods: This case-control study involved 175 preeclamptic and 253 normoevolutive pregnant women. The polymorphisms were genotyped by real time PCR.

Genetic variation in oxidative stress and DNA repair genes in a Mexican population.

Background: Oxidative stress has been associated with several complex diseases. Effects generated as a result of oxidative stress may be modulated by various genes. Variation in these genes, particularly when located within coding or regulating regions, may be the primary cause of this modulation.