Prostate radiotherapy in patients with metastatic hormone-sensitive prostate cancer: A systematic review and -analysis of randomised controlled trials.

Introduction: The incidence of synchronous metastatic hormone-sensitive prostate cancer (mHSPC) is rising with the increasing use of next-generation imaging. Local radiotherapy (RT) was shown to improve survival in patients with mHSPC; however, new data require a re-assessment of the indication and value of local RT in mHSPC.

Methods: In this prospectively registered systematic review and -analysis (CRD42025648251), we searched MEDLINE, Scopus, CENTRAL, and Google Scholar in March 2025 for phase 3 RCTs evaluating the addition of RT to systemic therapy to improve OS in mHSPC patients.

Electrospun polyvinyl alcohol/carboxymethyl cellulose loaded with Asphaltum Punjabianum (Shilajit) nanofibrous mats for potential cartilage regeneration applications.

Current developments in tissue engineering methods and conventional implants continue to face challenges in tackling the complex avascular characteristics of articular cartilage, hindering effective repair and tissue regeneration. To overcome these challenges, this study primarily aims to achieve a synergistic solution by processing Asphaltum Punjabianum (Shilajit) incorporated polyvinyl alcohol (PVA) and carboxymethyl cellulose (CMC) nanofibrous mats through electrospinning. The processed electrospun fibers were comprehensively analyzed through scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR), antimicrobial assay, degradation studies, surface roughness measurements, rheological studies, and assessment of cell viability.

Global Research Trends in Anticoagulation and Mechanical Thrombectomy for Iliofemoral Deep Vein Thrombosis: A Bibliometric Analysis (2000-2024).

This bibliometric study provides the first comprehensive analysis of global research trends, collaborative networks, and citation metrics related to anticoagulation and mechanical thrombectomy in iliofemoral deep vein thrombosis (DVT). Using Dimensions AI, 234 articles published between 2000 and 2025 were identified through a targeted search of terms including "iliofemoral DVT," "anticoagulation," and "mechanical thrombectomy." Data extracted included publication year, citation count, research category, author affiliation, country of origin, and co-authorship.

Advances in nano sensors for monitoring and optimal performance enhancement in photovoltaic cells.

Nanosensors have gained significant attention in recent years for improving energy conversion and storage performance in solar cells. These nanosensors, typically made from nanoparticles or nanowires, can be embedded within the solar cell to monitor parameters like temperature and light intensity. By monitoring these parameters, nanosensors provide real-time feedback and control to optimize the efficiency and performance of the solar cell.

A lightweight and robust authentication scheme for the healthcare system using public cloud server.

Cloud computing is vital in various applications, such as healthcare, transportation, governance, and mobile computing. When using a public cloud server, it is mandatory to be secured from all known threats because a minor attacker's disturbance severely threatens the whole system. A public cloud server is posed with numerous threats; an adversary can easily enter the server to access sensitive information, especially for the healthcare industry, which offers services to patients, researchers, labs, and hospitals in a flexible way with minimal operational costs.

Examining the Impact of Socioeconomic Factors and Lifestyle Habits on Obesity Prevalence Among Male and Female Adolescent Students in Asser, Saudi Arabia.

Background Understanding the relationships between obesity and lifestyle factors is essential for the effective prevention and management of obesity in youth. This study aimed to investigate the association between sociodemographic factors, lifestyle elements such as physical activity and social stress, and the prevalence of overweight and obesity among Saudi adolescents in the Aseer region. Methodology From December 2022 to March 2023, we conducted a cross-sectional study using the multi-stage stratified random sampling technique.

Congenital Talipes Equinovarus Management and Outcomes: The Experiences of Pediatric Tertiary Centers in Abha, Saudi Arabia.

Background: Congenital talipes equinovarus (CTEV), also known as clubfoot, describes a range of foot abnormalities usually present at birth (congenital) in which a baby's foot is twisted out of shape or position. In clubfoot, tendons are shorter than usual. Clubfoot is a fairly common birth defect and is usually an isolated problem for an otherwise healthy newborn.

Sustainable developments in near-dry electrical discharge machining process using sunflower oil-mist dielectric fluid.

In this study, a near-dry electrical discharge machining (NDEDM) process has been conducted using compressed air mixed with a low quantity of biodegradable refined sunflower oil (called oil-mist) to investigate the machining characteristics. The Box-Behnken method looks at how oil flow rate (OR), air pressure (AR), spark current (SC), and pulse width (PW) affect gas emission concentration (GEC), material removal rate (MRR), and surface roughness (SR). The TOPSIS (The Technique for Order of Preference by Similarity to the Ideal Solution) technique estimates the parameter optimal set for the best machining characteristics.

Smart Artificial Intelligence techniques using embedded band for diagnosis and combating COVID-19.

Recently, COVID-19 virus spread to create a major impact in human body worldwide. The Corona virus, initiated by the SARS-CoV-2 virus, was known in China, December 2019 and affirmed a worldwide epidemic by the World Health Organization on 11 March 2020. The core aim of this research is to detect the spreading of COVID-19 virus and solve the problems in human lungs infection quickly.

A New Era of National Guideline Development in Saudi Arabia.

Saudi Arabia's ambitious Vision 2030 project was launched in 2016 as a strategy for economic development and national growth, with 11 Vision Realization Programs put in charge of its implementation. The backbone of its Transformation Program for the Health Sector has been the definition of a new Model of Care aiming to deliver 42 coordinated interventions across 6 Systems of Care, with the development of clinical guidelines identified as a key cross-cutting intervention to foster the use of national, evidence-based practices across KSA, reduce care variation, and promote accountable care. This article provides an overview of the history, progress to date, and future outlook of the recently initiated National Guidelines Center in Saudi Arabia, established in collaboration between the Health Holding Company and the Saudi Health Council represented by its National Center for Evidence-based Medicine.

Baseline Assessment of Health Research Systems in Saudi Arabia: Harnessing Efforts and Mobilizing Actions.

Major transformations are taking place in the Kingdom of Saudi Arabia (KSA) to achieve the 2030 vision for the health sector. A key component in strengthening the health system is a strong research governance strategy that can support the decision-making process by providing timely and accurate evidence that reflects local context and needs. This paper sought to better understand governance structures and policies for health research systems and support clusters so that they function effectively.

Perceptions of Parents towards COVID-19 Vaccination in Children, Aseer Region, Southwestern Saudi Arabia.

Vaccines are an important part of the COVID-19 pandemic response plan. This cross-sectional study aims to assess the attitude and perception levels of parents toward COVID-19 vaccines for children aged 0-18 years in the Aseer region of Saudi Arabia. Data were analyzed using SPSS version 16.

Experience gained from the implementation of the Saudi TraumA Registry (STAR).

Background: Trauma registries are essential to trauma systems, to enable collection of the data needed to enhance clinical knowledge and monitor system performance. The King Saud Medical City (KSMC) in Riyadh, Kingdom of Saudi Arabia (KSA) is aiming to become a Level 1 Trauma Centre, and required a trauma registry in order to do so. Our objective was to establish the Saudi TraumA Registry (STAR) at the (KSMC) and ready it for national deployment.

Association of Non-Carious Cervical Lesions with Oral Hygiene Habits and Dynamic Occlusal Parameters.

Dentists routinely encounter non-carious cervical lesions (NCCLs) in daily clinical practices. The dental literature is contradictory regarding the occlusal etiology of NCCLs. NCCL is defined as the loss of dental structure at the cemento-enamel junction, with no association of bacteria.

Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017.

Background: The hallmark of Middle East respiratory syndrome coronavirus (MERS-CoV) disease is the ability to cause major health care-associated nosocomial outbreaks with superspreading events leading to massive numbers of cases and excessive morbidity and mortality. In this report, we describe a patient who presented with acute renal failure requiring hemodialysis and became a MERS-CoV superspreader, igniting a recent multihospital outbreak in Riyadh.

Material And Results: Between May 31 and June 15, 2017, 44 cases of MERS-CoV infection were reported from 3 simultaneous clusters from 3 health care facilities in Riyadh, Saudi Arabia, including 11 fatal cases.

Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV): Revision of screening strategies urgently needed.

Objectives: Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause frequent hospital outbreaks in Saudi Arabia, with emergency departments as the initial site of the spread of this virus.

Methods: The risk of transmission of MERS-CoV infection to healthcare workers (HCWs) was assessed in an outbreak in Riyadh. All HCWs with unprotected exposure to confirmed cases were tested after 24h of exposure.

Evaluation of Change in Knowledge and Attitude of Emergency Medicine Residents after Introduction of a Rotation in Emergency Medical Services and Disaster Medicine.

Background: Saudi Board of Emergency Medicine (SBEM) graduates are involved in a 1-month rotation in emergency medical services (EMSs) and disaster medicine. The purpose of this study was to evaluate change in knowledge and attitude of EM residents after the introduction of the EMS and disaster medicine rotation.

Materials And Methods: The study included 32 3-year SBEM residents.

Knowledge and awareness of Middle East respiratory syndrome coronavirus among Saudi and Non-Saudi Arabian pilgrims.

Objective: The current study was intended to evaluate the knowledge and awareness toward Middle East respiratory syndrome coronavirus (MERS-CoV) of pilgrims from Saudi Arabia and from different Arabian countries.

Methods: A prospective study was conducted among pilgrims from Saudi Arabia and those from other Arab nations. A total number of 2120 participants including 736 Saudi pilgrims (436 males and 300 females) and 1384 non-Saudi Arabian pilgrims (1384; 909 males and 475 females) were included in the study.

Knowledge and attitudes of Saudi populations regarding seasonal influenza vaccination.

The World Health Organization Global Vaccine Action Plan aims to accelerate the control of preventable diseases, including seasonal influenza; however, seasonal influenza vaccination reluctance persists. The current study aimed to assess the knowledge and attitudes of Saudi nationals regarding seasonal influenza vaccinations. An anonymous questionnaire was targeted to Saudi nationals for self-enrolment in this study.