Clinical outcomes of endoscopic submucosal dissection for residual neoplasia after incomplete resection of large nonpedunculated colorectal polyps: a large multicenter propensity match study (with video).

Background And Aims: Data on endoscopic submucosal dissection (ESD) for residual neoplasia after incomplete endoscopic resection (ER) of large nonpedunculated colorectal polyps (LNPCPs) remain scarce. We aimed to evaluate and compare outcomes of ESD in patients with treatment-naïve (control) lesions versus those with previous failed ER.

Methods: This was a multicenter propensity-score (PS) match study of ESDs performed for LNPCPs between January 2021 and September 2024.

Refractory Benign Duodenal Stenosis Successfully Treated With Endoscopic Spray Cryotherapy.

Benign duodenal stenosis is most commonly seen as a complication of peptic ulcer disease. Medical treatments include acid-blocking agents and eradication of infection. While endoscopic balloon dilatation is an effective treatment modality, frequent dilations and ultimately surgical repair are often needed for refractory cases.

Multipoint adjustable traction for endoscopic submucosal dissection using a helix tack suturing system: a case series.

Background And Aims: Optimal exposure of the submucosal plane is essential for effective endoscopic submucosal dissection (ESD). The application of traction improves visualization and resection efficiency, but most described techniques rely on nonadaptive single-point fixation.

Methods: We describe a novel multipoint, adjustable traction technique using the X-Tack Endoscopic Helix Tacking System.

Tips on pre-emptive hemostasis of large vessels during endoscopic full-thickness resection of a large gastrointestinal stromal tumor.

Background And Aims: Exposed endoscopic full-thickness resection is often necessary for the management of large subepithelial lesions or those extending deep into the GI wall. Despite advances in endoscopy, our toolbox for the prevention and management of bleeding from large vessels remains limited. This video case report demonstrates the successful removal of a large gastrointestinal stromal tumor in the fundus, with a focus on our endoscopic approach to the management of large peritoneal vessels.

Prospective analysis of endoscopic measurement of pyloric impedance planimetry and its association with clinical outcomes of gastric peroral endoscopic myotomy.

The functional luminal imaging probe (FLIP) assesses pyloric sphincter physiology. We prospectively used FLIP to evaluate the association between pyloric measurements and clinical outcomes of gastric peroral endoscopic myotomy (G-POEM) in patients with refractory gastroparesis.This was a single-center prospective trial of patients who underwent G-POEM between January 2022 and March 2024.

A Case of Transduodenal Endoscopic Ultrasound-Guided Biopsy of an Appendiceal Lesion.

Vermiform appendiceal cancers are rare and commonly diagnosed incidentally after appendectomy for acute appendicitis. Establishing a diagnosis and staging appendiceal cancer is important as the treatment options differ based on the subtypes of tumor and their spread in the peritoneum. The role of endosonography in tissue diagnosis of appendiceal cancer is limited.

Umbrella systematic review of potential quality indicators for the detection of dysplasia and cancer at upper gastrointestinal endoscopy.

Upper gastrointestinal (UGI) endoscopy lacks established quality indicators. We conducted an umbrella systematic review of potential quality indicators for the detection of UGI cancer and dysplasia. Bibliographic databases were searched up to December 2021 for systematic reviews and primary studies.

The Fatty Liver, Cirrhosis, and Liver Cancer Study (TENDENCY): Protocol for a Multicenter Case-Control Study.

Background: Hepatocellular cancer (HCC) is associated with high mortality, and early diagnosis leads to better survival. Patients with cirrhosis, especially due to nonalcoholic fatty liver disease and viral hepatitis, are at higher risk of developing HCC and form the main screening group. The current screening methods for HCC (6-monthly screening with serum alpha fetoprotein and ultrasound liver) have low sensitivity; hence, there is a need for better screening markers for HCC.

A root cause analysis system to establish the most plausible explanation for post-endoscopy upper gastrointestinal cancer.

BACKGROUND : Missing upper gastrointestinal cancer (UGIC) at endoscopy may prevent curative treatment. We have developed a root cause analysis system for potentially missed UGICs at endoscopy (post-endoscopy UGIC [PEUGIC]) to establish the most plausible explanations. METHODS : The electronic records of patients with UGIC at two National Health Service providers were examined.

Improving 30-day mortality after PEG tube placement in England from 2007 to 2019: a retrospective national cohort analysis of 87,862 patients.

Background And Aims: PEG has been associated with poor case selection and high mortality. We examined indications, 30-day mortality, and 7-day adverse events in a national cohort undergoing PEG tube insertion.

Methods: Adult patients undergoing their first PEG tube insertion from 2007 to 2019 were identified in the Hospital Episode Statistics database.

Can adjuncts to bowel preparation for colonoscopy improve patient experience and result in superior bowel cleanliness? A systematic review and meta-analysis.

Background: Bowel preparation for colonoscopy is often poorly tolerated due to poor palatability and adverse effects. This can negatively impact on the patient experience and on the quality of bowel preparation. This systematic review and meta-analysis was carried out to assess whether adjuncts to bowel preparation affected palatability, tolerability and quality of bowel preparation (bowel cleanliness).

Time to endoscopy for acute upper gastrointestinal bleeding: Results from a prospective multicentre trainee-led audit.

Background: Endoscopy within 24 h of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24 h of admission).

Methods: This prospective multicentre audit enrolled patients admitted with AUGIB who underwent inpatient endoscopy between November and December 2017.

Robotic-Arm Assisted Total Knee Arthroplasty Demonstrated Soft Tissue Protection.

Introduction: While total knee arthroplasty (TKA) procedures have demonstrated clinical success, occasionally intraoperative complications can occur. Collateral or posterior cruciate ligament injury, instability, extensor mechanism disruption, and tibiofemoral or patellofemoral dislocation are among a few of the intraoperatively driven adverse events prevalently ranked by The Knee Society. Robotic-arm assisted TKA (RATKA) provides a surgeon the ability to three-dimensionally plan a TKA and use intraoperative visual, auditory, and tactile feedback to ensure that only the desired bone cuts are made.

In-vivo three-dimensional knee kinematics during daily activities in dogs.

The canine knee is morphologically similar to the human knee and thus dogs have been used in experimental models to study human knee pathology. To date, there is limited data of normal canine 3D knee kinematics during daily activities. The objective of this study was to characterize 3D in-vivo femorotibial kinematics in normal dogs during commonly performed daily activities.

Accuracy of noninvasive, single-plane fluoroscopic analysis for measurement of three-dimensional femorotibial joint poses in dogs treated by tibial plateau leveling osteotomy.

Objective: To compare accuracy of a noninvasive single-plane fluoroscopic analysis technique with radiostereometric analysis (RSA) for determining 3-D femorotibial poses in a canine cadaver stifle joint treated by tibial-plateau-leveling osteotomy (TPLO).

Sample: Left pelvic limb from a 25-kg adult mixed-breed dog.

Procedures: A CT scan of the left pelvic limb was performed.

Accuracy of noninvasive, single-plane fluoroscopic analysis for measurement of three-dimensional femorotibial joint poses in dogs.

Objective: To compare accuracy of a noninvasive single-plane fluoroscopic technique with radiostereometric analysis (RSA) for determining 3-D femorotibial poses in a canine cadaver with normal stifle joints.

Sample: Right pelvic limb from a 25-kg adult mixed-breed dog.

Procedures: A CT scan of the limb was obtained before and after metal beads were implanted into the right femur and tibia.

Associations of self-report measures with gait, range of motion and proprioception in patients with lumbar spinal stenosis.

Introduction: Spinal stenosis is defined as neurogenic claudication due to narrowing of the spinal canal lumen diameter. As the disease progresses, ambulation and gait may be impaired. Self-report measures are routinely used in the clinical setting to capture data related to lumbar pain symptoms, function and perceived disability.

Efficacy of telmisartan and atenolol in management of essential hypertension.

Background: Telmisartan and atenolol are widely used in the management of essential hypertension. This study was conducted to compare the efficacy of these two drugs in management of patients of essential hypertension.

Methods: Diagnosed patients of essential hypertension were selected.

Preventive role of zinc chloride against toxicity of ciprofloxacin on the growing cartilage of Wistar albino rat litter.

Objective: To assess the preventive role of zinc chloride on toxicity of ciprofloxacin administration in Wistar albino rat litter. It was a Prospective experimental study. The study was carried out in the Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, Pakistan during March 2002 to February 2003 one year study.