Publications by authors named "Abdou Beziane"
Article Synopsis
- The study investigates the presence and importance of autoantibodies against lysobisphosphatidic acid (aLBPA) in patients with antiphospholipid syndrome (APS).
- It compares 91 patients with antiphospholipid antibodies—60 symptomatic and 31 asymptomatic—to 33 controls, finding a higher prevalence of aLBPA among patients.
- The research suggests that testing for aLBPA alongside conventional antiphospholipid antibodies may help in managing APS, especially in deciding if asymptomatic patients should receive preventive treatment.
Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49).
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- The study assessed the clinical utility of IgA antibodies in patients with antiphospholipid syndrome (APS), particularly focusing on IgA aβ2GPI antibodies.
- The analysis of 439 patients revealed a significant presence of aβ2GPI IgA antibodies (16% in patients vs. 1% in controls), which were linked to thrombosis and systemic lupus erythematosus (SLE).
- Findings suggest the identification of specific target domains in aβ2GPI IgA could help evaluate thrombotic risk in SLE patients, highlighting the potential importance of these antibodies in clinical settings.