Ultra-rapid lispro or fast-acting aspart compared to standard insulin lispro and aspart using closed-loop insulin therapy: a systematic review and meta-analysis of randomized control trials.

Background: Ultra-rapid-acting insulin (URAI) improves glycemic control by reducing variability; however, optimal strategies for its use, especially within hybrid closed-loop (HCL) insulin delivery systems, remain unclear. This meta-analysis assesses the efficacy and safety of combining URAI with HCL systems in maintaining the euglycemic range and reducing glycemic excursions.

Methods: We systematically searched PubMed, Scopus, Cochrane Library, Web of Science, and related article citations for relevant studies.

Ischemic heart disease awareness in Egypt's aging population: findings from a national cross-sectional study.

Background: Ischemic heart disease (IHD) remains a leading cause of mortality among the elderly population, particularly in low- and middle-income countries like Egypt, where public health infrastructure may struggle to meet the needs of a growing aging population. Awareness of the risk factors and warning signs associated with IHD is critical for early detection and intervention. This study aimed to evaluate the level of awareness and knowledge regarding IHD risk factors and warning signs among elderly individuals in Egypt, focusing on differences between urban and rural populations.