What's the TEE: Metrics of Temperature Extremes in Europe NUTS Regions (1980-2024).

We generate datasets quantifying extreme temperature exposure in Europe using a variety of metrics at two sub-national spatial scales (NUTS 2 and NUTS 3) and three temporal scales (daily, extreme temperature wave, and yearly) from 1980-2024. These datasets capture the breadth of temperature metrics used in epidemiology, demography and environmental literature with 67 different metrics: including regionally-unusual temperature events (defined as temperatures above/below the 95/5 percentile of historical temperatures) and periods of sustained (consecutive day) exposure to extreme temperatures. Although publicly available, climate data format and spatial resolution rarely matches the structure, scale, and extent used to disseminate government statistics on health, economic, and demographic variables, and manipulating raw data is computationally expensive.

Examining the Relationship Between HIV-Related Stigma and the Health and Wellbeing of Children and Adolescents Living with HIV: A Systematic Review.

Human immunodeficiency virus (HIV) affects millions of people globally. The associated stigma remains a challenge for individuals living with HIV and children and adolescents face the additional challenge of withstanding the peer, pubertal and identity challenges associated with growing up. The current systematic review aimed to define and explore the major stigma-related challenges of children and adolescents from their own perspectives.

Acceleration of Bone Regeneration Induced by a Soft-Callus Mimetic Material.

Clinical implementation of endochondral bone regeneration (EBR) would benefit from the engineering of devitalized cartilaginous constructs of allogeneic origins. Nevertheless, development of effective devitalization strategies that preserves extracellular matrix (ECM) is still challenging. The aim of this study is to investigate EBR induced by devitalized, soft callus-mimetic spheroids.

Short-Term Immobilization Promotes a Rapid Loss of Motor Evoked Potentials and Strength That Is Not Rescued by rTMS Treatment.

Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation (rTMS) could prevent any decline. Twenty-four healthy young males (20 ± 0.