The System-Wide Medication for Opioid Use Disorder (SW-MOUD) program: A description of program implementation.

Medication for opioid use disorder (MOUD) is an evidence-based treatment for opioid use disorder (OUD). However, only a small proportion of eligible patients receive MOUD, due in part to access barriers and the complex medical needs of this population. Provision of MOUD traditionally occurs in ambulatory opioid treatment programs that operate separately from other providers, making it difficult to address patient needs comprehensively during health care encounters.

Self-administered gerocognitive examination (SAGE) aids early detection of cognitive impairment at primary care provider visits.

Introduction: Current estimates indicate that up to 50-75% of dementia cases are undiagnosed at an early stage when treatments are most effective. Conducting robust accurate cognitive assessments can be time-consuming for providers and difficult to incorporate into a time-limited Primary Care Provider (PCP) visit. We wanted to compare PCP visits with and without using the self-administered SAGE to determine differences in identification rates of new cognitive disorders.

Initiation of medication for opioid use disorder across a health system: A retrospective analysis of patient characteristics and inpatient outcomes.

Objectives: Medication for opioid use disorder (MOUD) has gained significant momentum as an evidence-based intervention for treating opioid use disorder (OUD). The purpose of this study was to characterize MOUD initiations for buprenorphine and extended release (ER) naltrexone across all care sites at a major health system in the Midwest and determine whether MOUD initiation was associated with inpatient outcomes.

Methods: The study population comprised patients with OUD in the health system between 2018 and 2021.

An Ambulatory Care Clinic and Community Pharmacy Collaboration to Address Prescription Abandonment.

Purpose: The purpose of this research is to evaluate a collaborative workflow aimed at decreasing prescription abandonment.

Setting: A federally qualified health center and a 340B contracted grocery store-based community pharmacy.

Practice Workflow: An ambulatory care clinic with an established partnership with a community pharmacy chain identified a need to decrease prescription abandonment rates.

Impact of a Pharmacist-Provided Spirometry Service on Access to Results in a Primary Care Setting.

Objectives: The primary objective of this study was to determine the effect of a pharmacist-provided spirometry service within a federally qualified health center on the percentage of spirometry referrals completed with results reviewed by the ordering provider. Secondary objectives evaluated differences between internal and external referrals, medication recommendations made by the pharmacist, and revenue brought in by the service.

Methods: Chart reviews were completed to determine the referral completion rates between patients who received a spirometry referral before (December 2014-September 2015) and after (January 2016-October 2016) the implementation of the pharmacy-provided spirometry service.

Seasonal modulation of testosterone during breeding of the rufous-collared sparrow (Zonotrichia capensis australis) in Southern Patagonia.

The roles of testosterone (T) during reproduction are often complex and vary among and within vertebrate taxa and locations, making general hypotheses relating T to breeding behavior and success difficult to integrate. In birds, T is thought to influence degrees of territoriality and associated aggression in males to maximize breeding success. Importantly, most work supporting these ideas has been conducted in the Northern Hemisphere.

Modulation of androgens in southern hemisphere temperate breeding sparrows (Zonotrichia capensis): an altitudinal comparison.

Most work investigating modulation of testosterone (T) levels in birds has focused on northern temperate and Arctic species, and to a lesser degree, tropical species. Studies exploring modulation of T in birds in temperate regions of the Southern Hemisphere are lacking. Here we explore patterns of T secretion across the breeding season in two populations of temperate Zonotrichia capensis in Chile, located only 130 km apart, but separated by 2000 m in elevation.

Seasonal and social modulation of testosterone in Costa Rican rufous-collared sparrows (Zonotrichia capensis costaricensis).

Previous work shows that most birds breeding in northern temperate regions adjust production of testosterone in response to stage of the breeding cycle and in some cases following social interactions. In contrast, prior research suggests that tropical breeding birds are less likely to modulate testosterone in response to social interactions (the propensity to increase testosterone in response to social instability is known as the challenge hypothesis). To further test the challenge hypothesis in tropical birds, we investigated whether variation in season affects reproductive condition, aggressive behavior, and social modulation of testosterone in two populations of Costa Rican rufous-collared sparrow, Zonotrichia capensis costaricensis.

Disentangling the effects of environment and life-history stage on corticosterone modulation in Costa Rican rufous-collared sparrows, Zonotrichia capensis costaricensis.

This study explores the factors that influence modulation of baseline corticosterone levels and the hypothalamo-pituitary-adrenal cortex (HPA) axis response to stress in Costa Rican rufous-collared sparrows (Zonotrichia capensis costaricensis). Individuals in our study population vary in their timing of breeding and molt. Thus, at multiple times of the year, we were able to investigate how the HPA axis changes with life-history stage (breeding, molt) and the interaction of season and life-history stage.

Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements.

DNA methylation within the promoter region of human LINE1 (L1) transposable elements is important for maintaining transcriptional inactivation and for inhibiting L1 transposition. Determining methylation patterns on the complementary strands of repeated sequences is difficult using standard bisulfite methylation analysis. Evolutionary changes in each repeat and the variations between cells or alleles of the same repeat lead to a heterogeneous population of sequences.

Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules.

Epigenetic inheritance, the transmission of gene expression states from parent to daughter cells, often involves methylation of DNA. In eukaryotes, cytosine methylation is a frequent component of epigenetic mechanisms. Failure to transmit faithfully a methylated or an unmethylated state of cytosine can lead to altered phenotypes in plants and animals.