Double claw construct with hooks for proximal fixation in adolescent idiopathic scoliosis: a randomized controlled trial.

Purpose: Proximal fixation in adolescent idiopathic scoliosis (AIS) surgery is a matter of discussion. All screw (AS) constructs provide better coronal correction than hybrid constructs, but high thoracic pedicle screw placement can be challenging. This study investigated whether an AS-construct provides better correction than a proximal double hook-claw (PH) construct.

AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells.

Introduction: The Gardasil-4 vaccine targets HPV types 6, 11, 16 and 18 and is formulated with amorphous alum. Cervarix targets HPV types 16 and 18 using AS04 (Al(OH)3 + TLR4 agonist MPL) to enhance immune response. Cervarix elicits higher cross-protection against other high-risk HPV types, likely mediated by AS04.

Understanding stress regulation in relation to pathological personality traits: The role of Detachment and Negative Affect.

Objectives: The extent to which the pathological personality traits of Detachment and Negative Affect influence psychophysiological responses to stress is insufficiently explored. This pilot study aimed to investigate how these traits account for variations in perceived stress, and emotional and physiological responses to stress.

Design & Methods: 434 students (87 % female) participated in a cross-sectional study, in which the association between trait levels and perceived stress was assessed.

Fast track to environmentally adapted rhizobia for growing soybean at northern latitudes using citizen science.

Soybean serves as a crucial source of plant-based protein for human diets. Recently, there is a growing incentive to extend the range of this crop to more northern latitudes, in order to enable profitable soybean production in Europe. To reach economic yields, soybean requires inoculation with symbiotic, diazotrophic rhizobial bacteria.

An UHPLC-HRMS-Based Untargeted Metabolomics Approach to Explore the Effects of Bacterial Endophyte Co-Culture on (L.) Tausch Cell Suspension Metabolome.

Colonization of plant tissues by bacterial endophytes might lead to qualitative and quantitative changes in secondary metabolites (SMs). In this work, in vitro co-culture experiments were performed using cell suspensions of the medicinal plant and eight of its bacterial endophytes. An untargeted metabolomics approach using Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry (UHPLC-HRMS) was employed to investigate plant-microbe interactions.