Genoprotective Properties of para-Tyrosol against Doxorubicin-Induced DNA Damage in Sperm and Testicular Tissue Cells of Rats.

The effect of para-tyrosol (PT), a hydroxyalkylphenol exhibiting antioxidant properties, on the level of DNA damage in testicular tissue cells and sperm of rats treated with doxorubicin was studied using the DNA comet assay. N-acetylcysteine (NAC) was used as a reference drug. It was found that both drugs reduced the number of DNA breaks in rat testicular tissue cells (by 46-48%).

Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine.

The receptor mechanism of the antinociceptive effect of the diterpene alkaloid songorine was investigated in an experiment on mice. Antagonists of peripheral opioid, κ-opioid, and cannabinoid 1 receptors eliminated the analgesic effect of songorine. These findings suggest that these receptors are involved in the antinociceptive action of songorine.

Regenerative Potential of Granulocyte Colony-Stimulating Factor Immobilized by Using Electron-Beam Synthesis Nanotechnology in an Experimental Model of Ovarian Reserve Depletion.

The pharmacological activity of granulocyte CSF (G-CSF) immobilized using electron-beam synthesis nanotechnology (imG-CSF) was evaluated in an experimental model of ovarian reserve depletion. The effectiveness of the drug was compared with that of its unmodified form. Depletion of the ovarian follicular pool in female Sprague-Dawley rats was caused by a single intravenous injection of the antitumor drug etoposide in the maximum tolerated dose.

Assessment of Ante- and Postnatal Development of the Offspring of Male Rats Crossed in Delayed Periods after Treatment with Methotrexate in Low Doses.

We studied ante- and postnatal development of the offspring of intact female rats crossed with males injected with low doses of methotrexate 3 and 6 months before mating. The time of crossing corresponded to the manifestation of the cytostatic effect on spermatogonial stem cells. The offspring of methotrexate-treated males was characterized by increased preimplantation losses and fetal growth restriction in the antenatal period and inhibition of physical development, delayed formation of sensory-motor reflexes, and impaired learning abilities in the postnatal period.