Safety of Minimally Invasive Sublobar Pulmonary Metastasectomy in the Frail Patient.

Background And Objectives: Minimally invasive (MI) pulmonary metastasectomy may improve access in frail patients who are at high-risk for complications after thoracotomy. We compared postoperative complications among frail and non-frail patients undergoing pulmonary metastasectomy.

Methods: The Nationwide Readmissions Database (2017-2019) identified adult patients who underwent pulmonary metastasectomy.

Circadian variation in MGMT promoter methylation and expression predicts sensitivity to Temozolomide in glioblastoma.

Purpose Recent studies show that glioblastoma (GBM) is more sensitive to Temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent TMZ efficacy, suggesting that circadian regulation of this DNA repair enzyme underlies daily TMZ sensitivity. Here, we tested the hypotheses that MGMT-promoter methylation and protein abundance vary with time-of-day in GBM, resulting in daily rhythms in TMZ efficacy.

ESPWA: a deep learning-enabled tool for precision-based use of endocrine therapy in resource-limited settings.

Background: Cancer morbidity disproportionately affects patients in low- and middle-income countries (LMICs), where timely and accurate tumor profiling is often nonexistent. Immunohistochemistry-based assessment of estrogen receptor (ER) status, a critical step to guide use of endocrine therapy (ET) in breast cancer, is often delayed or unavailable. As a result, ET is often prescribed empirically, leading to ineffective and toxic treatment for ER-negative patients.

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

Unlabelled: Emerging and re-emerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant viral variants. Hence, there is an urgent need for additional broad spectrum antiviral therapeutic strategies.

Trait specialization facilitates autonomous selfing ability in a mixed-mating plant.

Premise: Transitions from outcrossing to selfing often drive the evolution of floral traits in a predictable way. However, these expectations are not as straightforward for mixed-mating systems. In this study, we examine variation in pollen-collecting hairs, a floral structure involved in secondary pollen presentation within Campanulaceae.