Publications by authors named "A R Intan-Shameha"

This study aimed to elucidate how edible bird's nest soup (EBNS) and edible bird's nest extract (EBNE) can protect the kidneys of obese rats from acute kidney injuries caused by a high-fat diet (HFD) via histological techniques. A total of 24 male Sprague-Dawley rats aged 12 weeks old were utilized in this study. The rats were randomly assigned (n = 6) to either the chow diet; HFD; HFD + EBNS (843.

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Article Synopsis
  • Breast cancer is the most common cancer among women, causing nearly 685,000 deaths in 2020, with epidermal growth factor receptors (EGFRs) linked to its development and treatment resistance.
  • EGFR has four homologues, and while gefitinib (GEF), a tyrosine kinase inhibitor for EGFR1, shows promise in treating breast cancer, clinical trials have not met expectations, highlighting a gap in understanding EGFR signaling.
  • Ongoing research into molecular pathways and the use of nanomedicines synthesized with GEF is crucial for improving treatment outcomes against breast cancer.
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Calcium carbonate has slowly paved its way into the field of nanomaterial research due to its inherent properties: biocompatibility, pH-sensitivity, and slow biodegradability. In our efforts to synthesize calcium carbonate nanoparticles (CSCaCONP) from blood cockle shells (), we developed a simple method to synthesize CSCaCONP, and loaded them with gefitinib (GEF) and paclitaxel (PTXL) to produce mono drug-loaded GEF-CSCaCONP, PTXL-CSCaCONP, and dual drug-loaded GEF-PTXL-CSCaCONP without usage of toxic chemicals. Fourier-transform infrared spectroscopy (FTIR) results reveal that the drugs are bound to CSCaCONP.

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Background And Aim: Back disorder is an ailment that often affects athletic and riding horses. Despite the rapidly growing equine athletic and equestrian activities, there is no documentation on the nature of equine back disorder (EBD) in Malaysian horses. The purpose of this study was to characterize EBD cases presented to University Veterinary Hospital, Universiti Putra Malaysia, between 2002 and 2017.

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The current study aimed at the investigating the potential use of phosphorylated neurofilament H (pNF-H) as a diagnostic biomarker for neurologic disorders in the horse. Paired serum and cerebrospinal fluid (CSF) samples (n=88) and serum only (n=30) were obtained from horses diagnosed with neurologic disorders and clinically healthy horses as control. The neurologic horses consisted of equine protozoal myeloencephalitis (EPM) (38 cases) and cervical vertebral malformation (CVM) (23 cases).

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