Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open-Label, Single-Arm, Phase IV Study.

Introduction: Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, targets tumor cells overexpressing human epidermal growth factor receptor 2 (HER2). This single-arm, phase IV study assessed the safety and efficacy of T-DM1 in Indian patients with HER2-positive, locally advanced, or metastatic breast cancer previously treated with trastuzumab and a taxane.

Methods: Patients received T-DM1 (3.

Femtosecond-laser-induced optical confinement with ping-pong motion.

We introduce a novel method using a kilohertz (kHz) amplified 800 nm laser for the first experimental confinement of microparticles within a single beam. This study demonstrates that high-energy kHz pulses can confine 1-μm-radius polystyrene beads in water within ∼26 μm. This approach utilizes the unique properties of high-energy pulsed lasers, distinct from continuous-wave and megahertz pulsed lasers traditionally used in optical trapping.

Comparing short term clinical outcomes of elective robot-assisted vs. non-robot assisted posterior lumbar interbody fusions: a NSQIP analysis.

Background: Symptomatic lumbar degenerative changes impact millions of patients per year. Recent technological advances have increased the usability of robot-assisted spinal fusions to treat this pathology. Although the safety profile of robotic systems appears favorable, the impact of robotics on surgical outcomes and efficiency remains unclear.

Beyond the Birds and Bees: Why Comprehensive Sexuality Education Is a Game-Changer for Everyone.

Comprehensive sexuality education (CSE) is a vital public health intervention that extends beyond basic biological facts to encompass emotional well-being, healthy relationships, and consent. This review explores the evolving landscape of sexuality education, examining diverse teaching methods, cultural and societal influences, and evidence-based strategies for effective implementation across all age groups and settings. By highlighting innovative practices, addressing persistent gaps and controversies, and advocating for inclusive models, this article positions sexuality education as a critical component of holistic health and public well-being, essential for fostering informed decision-making and promoting sexual rights globally.