Evaluation of clozapine forgiveness under imperfect adherence scenarios: a population pharmacokinetic simulation study.

Clozapine, the only drug approved by the FDA for treatment-resistant schizophrenia, operates within a narrow therapeutic range (0.35-0.60 mg/mL) and requires titration from 12.

An Approach to Drug Discovery via Ethnopharmacology and Sustainable Agriculture.

Ethnopharmacology is the study of traditional medicinal knowledge and its application in modern drug discovery. It combines ethnobotanical insights with scientific research to identify bio-active compounds with therapeutic potential. Sustainable agriculture refers to farming practices that maintain ecological balance, support biodiversity, and ensure the long-term availability of resources.

Detection of Pb and Fe ions in wastewater using a low cost portable optical sensor derived from green synthesized metal oxide nanoparticle on a paper substrate.

Background: Water contamination is a global challenge, primarily due to heavy metal ions like lead (Pb), iron (Fe), cadmium (Cd), andmercury (Hg) as well as dyes. These pollutants enter the ecosystem from industrial waste and runoff, accumulate in the environment and pose a high risk to humans, animals and plants. Various sensors, such as colorimetric sensors, and electrochemical sensors have been developed to detect these ions and dyes.

ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex.

Mitosis in spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a multinucleate schizont, while rapid male gametogony generates an octaploid nucleus before gamete formation.

Eco-Friendly Silver Nanoparticles Synthesis Method Using Medicinal Plant Fungal Endophytes-Biological Activities and Molecular Docking Analyses.

The integration of nanotechnology and green synthesis strategies provides innovative solutions in biomedicine. This study focuses on the biofabrication of silver nanoparticles (AgNPs) using , an endophytic fungus isolated from . The eco-friendly synthesis process employed fungal extracts as reducing and stabilizing agents thereby minimizing the need for hazardous chemicals.