Stability testing of HPCs and MNCs from apheresis products.

Background: Hematopoietic progenitor cells (HPCs) and mononuclear cells (MNCs) are critical components of cell-based therapies, including bone marrow transplantation and regenerative treatments. Evaluation of the characteristics of these products during collection, storage, and transport is essential for maintaining cell viability and functionality. In this study, we evaluated the functional and molecular stability of samples collected for the evaluation of fresh HPC and MNC products.

Artificial intelligence and infectious diseases: Scope and perspectives.

Artificial intelligence (AI) is set to permeate every facet of infectious disease practice-from prevention and public health surveillance to epidemic management and bedside care. Routine care data (laboratory results, medication orders, progress notes) and research-generated datasets now fuel state-of-the-art machine-learning (ML) pipelines that sharpen diagnosis, prognosis, antimicrobial stewardship, and, by combining both sources, accelerate drug discovery. In diagnostics, deep networks that now flag pneumonia or tuberculosis on chest images are increasingly able to identify-and localize-virtually more infectious processes throughout the body, while simultaneously predicting pathogen identity and antimicrobial resistance from routine microbiology.

Lung ultrasonography for community-acquired pneumonia diagnosis.

Over the past two decades, several studies have assessed the performance of lung ultrasonography in the diagnosis of community-acquired pneumonia (CAP). The performance of this diagnostic tool, when used by clinicians other than radiologists, is excellent, with an area under the curve of 0.97, 92% sensitivity, and 93% specificity according to a recent meta-analysis including 5,108 patients.

Antibiotic combination indications for the treatment of community-acquired acute pneumonia.

Empirical dual combination therapy with beta-lactam and macrolide is often the standard treatment of community-acquired acute pneumonia (CAP) in adults hospitalized in non-intensive care units. However, several recent studies question this standard treatment. The present literature review analyzes available data that compare beta-lactam monotherapy and dual antibiotic therapies in moderate CAP.

Indications for corticosteroids in the treatment of Community-Acquired pneumonia.

Preceding guidelines on treatment and management of community-acquired pneumonia (CAP) do not endorse systematic use of corticosteroids. The data in the literature show contradictory results; while some have suggested clinical improvement in cases of severe CAP, others have reported no significant benefit. The recent CAPE-COD trial demonstrated a marked reduction of mortality and intubation through early hydrocortisone treatment (200 mg/d).