Seroincidence rate of typhoidal in children in Kenya.

Enteric fever, caused by serovars Typhi and Paratyphi, causes significant morbidity and mortality globally. Surveillance is limited by the lack of reliable diagnostic assays, leading to major gaps in understanding the population-level burden in low- and middle-income countries. We applied a novel serologic tool measuring anti-IgG responses to Hemolysin E (HlyE) to assess infection rates in Kenyan children from four communities: two in western Kenya (Kisumu and Chulaimbo) and two in coastal Kenya (Ukunda and Msambweni).

Modelling the effects of precipitation and temperature on malaria incidence in coastal and western Kenya.

Background: Malaria continues to plague sub-Saharan Africa despite great efforts geared towards its mitigation. In Kenya alone, 70% of the population remains at risk for malaria every year. Malaria is spread by Anopheles mosquitoes carrying the Plasmodium parasite, and displays a complex ecology with various socio-economic, biophysical factors and meteorological predictors, particularly temperature and precipitation, associated with the occurrence of the disease.

School and home-based educational intervention in urban Kenya: Sustained improvements in knowledge, attitudes, and practices for Aedes aegypti control.

Aedes aegypti mosquitoes are the primary vectors for important arboviral health threats including chikungunya (CHIKV) and dengue (DENV) viruses, primarily breeding in domestic plastic containers. Previous studies have highlighted a severe lack of knowledge about non-malarial mosquito-borne diseases in Kenya, so we proposed a household and school-based educational intervention in urban coastal Kenya to determine whether it could bring about long-term improvements in knowledge, attitudes, and practices related to the source reduction of arboviral disease vectors. In this cluster-randomized controlled trial, 249 households from 5 villages were placed in the intervention arm and 243 households from 5 other similar villages were placed in the control arm.

Temporal Variation and Human Host Predominance in from Coastal and Western Kenya: Insights from Pooled Blood Meal Metagenomics.

is the primary vector of arboviral diseases such as dengue, chikungunya, yellow fever, and Zika, posing significant global health and economic challenges. The effective control of this mosquito species requires understanding its seasonality, feeding behavior, and ecological dynamics. Modern molecular techniques, such as amplicon metagenomic sequencing, provide insights into vector-host interactions and feeding patterns.

Yellow Fever Virus Genotyping Tool Using RT-qPCR Followed by Nucleotide Sequencing and Phylogenetic Analysis.

Yellow fever is an infectious disease preventable by vaccination. The vaccine is composed of a live attenuated virus that, in some cases, may lead to adverse events, as neurological or viscerotropic disease. The differentiation between serious adverse vaccine events and natural infection by yellow fever virus is essential, especially in yellow fever endemic areas.