Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.

Neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, spinal cord injuries, and traumatic brain injuries, represent substantial global health challenges due to their chronic and often progressive nature. While allopathic medicine offers a range of pharmacological interventions aimed at managing symptoms and mitigating disease progression, it is accompanied by limitations, including adverse side effects, the development of drug resistance, and incomplete efficacy. In parallel, phytochemicals-bioactive compounds derived from plants-are receiving increased attention for their potential neuroprotective, antioxidant, and anti-inflammatory properties.

Adenomatoid Odontogenic Tumor Arising From a Dentigerous Cyst in a 10-Year-Old Patient: A Case Report and Literature Review.

Adenomatoid odontogenic tumor (AOT) is a benign, well-encapsulated odontogenic lesion that typically presents as a slow-growing, asymptomatic mass. Surgical enucleation or curettage remains the treatment of choice due to the tumor's non-invasive nature and well-defined borders, which facilitate complete removal with minimal risk of recurrence. Interestingly, some studies have suggested that AOTs may occasionally arise within pre-existing dentigerous cysts, indicating a possible developmental relationship between the two entities.

Immunogenicity, safety and adverse events of sequential vaccination with a 10-valent pneumococcal conjugate vaccine (PCV10) and PPSV23 compared with PPSV23 alone in systemic lupus erythematosus.

Background: SLE has increased risk of invasive pneumococcal disease due to immune dysregulation and immunosuppression. European Alliance of Associations for Rheumatology recommendations suggest sequential vaccination with conjugate vaccine, followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23). However, data on immunogenicity of sequential vaccination in SLE are limited.

Adrenal Insufficiency after Steroid Therapy in Children with Steroid-Sensitive Nephrotic Syndrome: A Cross-sectional Study.

Introduction: Glucocorticoid-induced adrenal insufficiency (AI) is underestimated and under-reported in children with nephrotic syndrome (NS). This study aimed to estimate the prevalence of AI in children with steroid-sensitive NS, defined by serum cortisol level <18 mcg/dL 30 minutes after low-dose adrenocorticotropin stimulation test (LDST) and/or baseline (8 AM) serum cortisol level <5 mcg/dL, 4-12 weeks after stopping steroid therapy.

Methods: In this cross-sectional study, 73 children with steroid-sensitive NS, in remission and off steroids for 4-12 weeks, were enrolled from the Paediatrics Department at a tertiary care hospital.

The rise of Extended spectrum β-lactamase (ESBL) producing ceftriaxone resistant Salmonella Typhi from western Rajasthan, India.

Introduction: Typhoid fever, caused by Salmonella Typhi and Paratyphi, remains a sig-nificant public health concern, particularly in developing countries. The emergence of antimicrobial resistance, including resistance to first-line drugs, fluoroquinolones, and the development of re-sistance to ceftriaxone, poses a significant threat to effective treatment.

Methods: This study investigated extended-spectrum β-lactamase (ESBL)-producing Salmonella Typhi isolates from blood samples of patients with suspected typhoid fever at a tertiary care hospital in Western Rajasthan, India, between April 2022 and May 2024.