PRACT-India: Practical Recommendations on Acne Care and Medical Treatment in India-A Modified Delphi Consensus.

Acne vulgaris is a prevalent dermatological condition, yet clear, region-specific management guidelines, particularly for India's diverse population, remain limited. Effective acne management extends beyond pharmacologic therapy, emphasizing proper skincare, patient education, and adherence strategies. This consensus aims to provide tailored, evidence-based recommendations for optimizing acne treatment in the Indian context.

Protective efficacy of emodin in Swiss Albino mice induced with Dalton Ascitic lymphoma.

Emodin is a plant-derived natural compound with potential anti-cancer/tumor properties. In this study, we have evaluated the therapeutic efficacy of emodin as an anti-lymphoma drug in vivo in the Swiss Albino mice induced with Dalton Ascitic lymphoma (DAL). The Swiss Albino mice were induced with lymphoma by injecting the DAL cells intraperitonially and treated with the emodin or a standard drug methotrexate or a vehicle.

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid.

Introduction: Adeno-associated virus (AAV)-mediated gene therapy is a promising approach to treat genetic disorders, offering advantages such as high transduction efficiency, diverse tissue tropism, and an acceptable safety profile. However, the immunogenicity of AAV vectors, particularly the activation of AAV capsid-specific CD8 T cells, significantly impacts therapeutic efficacy and safety. Capsid-specific T cell responses are currently monitored in the clinic using overlapping peptides, which do not represent the naturally presented capsid immunopeptidome.

Ultrack: pushing the limits of cell tracking across biological scales.

Tracking live cells across two-dimensional, three-dimensional (3D) and multichannel time-lapse recordings is crucial for understanding tissue-scale biological processes. Despite advancements in imaging technology, accurately tracking cells remains challenging, particularly in complex and crowded tissues where cell segmentation is often ambiguous. We present Ultrack, a versatile and scalable cell tracking method that tackles this challenge by considering candidate segmentations derived from multiple algorithms and parameter sets.

Significance of Pulmonary Vascular Dysfunction in Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is frequently accompanied by abnormalities of the pulmonary vasculature. This vasculopathy spans the spectrum from mild vascular dysfunction to pulmonary hypertension, which on rare occasions can be severe. Given the worldwide prevalence of COPD, it is conceivable that the morbidity and mortality associated with pulmonary vascular dysfunction have been vastly underappreciated, especially in countries and regions where the infrastructure and resources to define the magnitude of the problem are often limited.