Dimethyl fumarate is an inhibitor of pathological angiogenesis.

Vascular endothelial growth factor (VEGF), a pro-angiogenic molecule, supports blood vessel growth during wound healing but also drives pathological neovascularization in blinding eye diseases such as neovascular age-related macular degeneration (nAMD). Dimethyl fumarate (DMFu), an FDA-approved drug for multiple sclerosis, has previously shown promising anti-inflammatory properties in retinal pigment epithelium, a crucial structure disrupted by nAMD. Here, we extend the multi-phenotypic therapeutic potential of DMFu by discerning the anti-angiogenic capabilities of DMFu in choroidal and retinal endothelial cells.

Oral PrEP use and intention to use long-acting PrEP regimens among MSM accessing PrEP via governmental and non-governmental provision pathways, 20 European countries, October 2023 to April 2024.

BACKGROUNDPre-exposure prophylaxis (PrEP) provision routes across Europe differ notably between governmental and non-governmental pathways. The introduction of long-acting (LA)-PrEP may further diversify provision dynamics.AIMWe investigated disparities in PrEP access and whether access pathways determine oral PrEP use patterns and LA-PrEP intention among PrEP-experienced men who have sex with men (MSM).

Utilizing PBF-LB/M AlSI10Mg alloy post-processed via KOBO-extrusion and subsequent cold drawing to obtain high-strength wire.

This study investigates the efficacy of a multi-stage thermo-mechanical processing route, comprising KOBO extrusion followed by cold drawing, for enhancing the mechanical properties of AlSi10Mg alloy produced via by powder bed fusion laser beam melting (PBF-LB/M). The objective was to develop high-strength wires from this additively manufactured alloy. The microstructural evolution throughout the processing sequence was characterized using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and transmission electron microscopy (TEM).

Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.

We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure.