[Genetic profiling of parathyroid tumours: lifting the veil of mystery].

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomous secretion of parathyroid hormone by altered parathyroid glands. In most cases PHPT is a sporadic disease, 5-10% of observations are genetically determined syndromal and non-syndromal forms. Studies of families with hereditary forms of PHPT have led to the discovery of key oncosuppressor genes and proto-oncogenes whose somatic mutations underlie the development of many sporadic parathyroid tumors.

Case report: Relapse of intrathyroidal parathyroid carcinoma in a patient with novel variants in and genes.

Parathyroid carcinoma (PC) is one of the rarest malignant neoplasms of the human endocrine system, with a prevalence of approximately 0.005% of all oncological diseases. Despite its indolent course, PC generally relapses in about 40%-60% of cases.

[The role of immunohistochemical examination in the differential diagnosis of atypical tumors and carcinomas of parathyroid glands].

Unlabelled: Differential diagnosis of atypical parathyroid tumors (APT) and parathyroid carcinomas (PC) is important in determining further management and prognosis. Morphologic diagnosis is sometimes difficult, in which case it is supplemented by immunohistochemical (IHC) examination.

Objective: Studying the role of IHC analysis in the differential diagnosis of APT and PC.