Mental health disorders among people living with HIV in sub-Saharan Africa: a scoping review protocol.

Background: The mental health of people living with HIV (PLWH) is a growing concern globally, particularly in sub-Saharan Africa (SSA), where there is limited access to mental healthcare, with evidence showing high levels of depression, anxiety and neurocognitive disorders among this population. While Mental Health Disorders (MHDs) can impede HIV care and promote adverse health outcomes, there is limited literature on MHDs among PLWH. This scoping review will explore the existing literature on the burden and factors associated with MHDs among adults living with HIV in SSA.

KneEZ Clear, an Effective Tissue Clearing Protocol to Study Musculoskeletal Tissues in the Mouse.

Wholemount, 3-dimensional (3D) tissue imaging holds significant promise for analyzing heterogeneous musculoskeletal tissues, such as knee joints, that demand time- and labor-intensive processing using traditional histological methods. Current musculoskeletal clearing protocols rely on either solvent-based tissue clearing, which substantially alters the size and architecture of cleared tissues, possibly compromising downstream quantification and perhaps more importantly reducing signal from endogenous fluorescent reporters, or on expensive and time-consuming hydrogel-based approaches that requires specialized equipment. While aqueous-based clearing overcomes these challenges, there is a clear need for a method that is optimized for clearing musculoskeletal tissues and that can easily be implemented in a standard lab environment.

and secondary metabolites exhibit neuroprotective potential: insights from in vitro, ex vivo and computational models.

Cinnamon and coriander plants are sources of popular spice products in different cuisines prepared by many people worldwide. The inhibitory effect of cinnamon bark and coriander seeds aqueous extracts on butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) activities, and their antioxidant properties were investigated using in vitro, molecular docking and molecular dynamics (MD) computational models. Standard experimental methods were employed to determine the plant extracts' antioxidant and enzyme-inhibitory capacities.

CLINICO-HISTOPATHOLOGIC PRESENTATION OF A NIGERIAN CHILD WITH TORSION OF THE EPIDIDYMAL APPENDAGE: A CASE REPORT.

Introduction: Torsion of the appendix of the epididymis is a rare cause of acute scrotum. However, it can be distinguished from testicular torsion by its insidious onset and localizable tenderness. In addition, colour Doppler ultrasonography has characteristic findings in torsion of the testicular appendage.

Investigating the effect of SGLT2 inhibitors on cardiovascular related health status in HFmrEF and HFpEF: systematic review and meta analysis.

Background And Aims: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as an integral component of heart failure management, with evidence supporting their benefits across a broad spectrum of ejection fractions. However, their impact on quality of life (QoL) in patients with heart failure with mildly reduced (HFmrEF) and preserved ejection fraction (HFpEF) remains underexplored. This systematic review and meta-analysis aim to evaluate the effects of SGLT2i on QoL compared to standard therapy in these patient populations.