Cost-effectiveness of operative versus nonoperative treatment of lateral compression type 1 pelvic fractures.

Background: Lateral compression type 1 (LC1) pelvic fractures are common injuries with ongoing debate regarding the cost-effectiveness of operative versus non-operative treatment. The goal of this study is to evaluate the cost-effectiveness of operative versus non-operative management for lateral compression type 1 (LC1) pelvic fractures, using pain (Brief Pain Inventory, BPI) and functional recovery (Majeed Pelvic Score, MPS) as outcome measures across early follow-up intervals.

Methods: A decision tree model was developed to analyze the costs and outcomes of operative and non-operative management for LC1 fractures.

Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression.

Pemphigus vulgaris is a B cell-mediated autoimmune disease characterized by autoantibodies targeting desmoglein-3 (Dsg3), a critical adhesion molecule in epithelial tissues. Current treatments rely on broad immunosuppression, highlighting the need for more targeted therapeutic approaches in pemphigus vulgaris and other autoantibody-driven disorders. We engineered a therapeutic fusion protein consisting of the pathogenic domains of Dsg3 linked to either human immunoglobulin G1 (IgG1) or mouse IgG2a (Dsg3-Fc).

Trends in hemiarthroplasty and total hip arthroplasty for femoral neck fractures: Surgeon or patient driven?

Introduction: The primary objective was to analyze the trends in hemiarthroplasty (HA) and total hip arthroplasty (THA) for adult patients with fractures (FNFs), with a focus on geriatric population, over the past two decades. The secondary objectives were to compare outcomes between HA and THA and evaluate its association with patient- and surgeon- specific factors.

Methods And Materials: Design: Retrospective cohort.

The Relationship Between Radiographic Osteoarthritis, Step Counts, and Pain Levels in Patients Undergoing Hip and Knee Arthroplasty.

Introduction: Osteoarthritis (OA) severity does not always correlate with clinical symptoms in joint arthroplasty candidates. Identifying metrics that correlate with clinical symptoms may inform strategies for OA treatment and optimization of arthroplasty timing. This study investigates the relationship between the novel metric of preoperative step count (SC) and radiographic OA severity compared with standard measures of preoperative pain/function.

Segmentation and finite element analysis in orthopaedic trauma.

Background: Finite Element Analysis (FEA) has evolved into a crucial tool in orthopaedic trauma research and clinical practice. This review explores the broad applications of FEA in orthopedic surgery.

Main Body: FEA involves several steps, including geometry representation, segmentation, 3D rendering, meshing, material property assignment, defining boundary conditions, and specifying contact conditions.