Exploring Diazo Compounds for the Divergent Electro-Cascade Sequence and S-H Insertion Reaction.

We have explored the reactivity of diazo compounds under electrochemical conditions to establish a cascade sequence of thiolation/cyclization/reduction reactions. Electrolyzing styryl diazo imides and aryl thiols enables direct access to a single diastereoisomer of 2,5-pyrrolidine-dione-fused thiochromans in good yield under mild and metal-free conditions. Notably, a tunable reactivity has been achieved via S-H insertion at the diazo center in modified reaction conditions.

Endoscopic repair of nasal septal perforation with anterior ethmoidal artery flap using tunnel technique.

Purpose: Septal perforations (SPs) present a distinct challenge. There are many described surgical approaches with variable success rates. The goal of this study is to describe a new technique in repairing SP.