Publications by authors named "European Pregnancy And Paediatric Infections Cohort Collaboration Eppicc"
Outcomes of etravirine-based antiretroviral treatment in treatment-experienced children and adolescents living with HIV in Europe and Thailand.
European Pregnancy And Paediatric Infections Cohort Collaboration Eppicc
,
Alex Lyons
,
Lindsay Thompson
,
Elizabeth Chappell
,
Luminita Ene
Antivir Ther
June 2022
Article Synopsis
- Etravirine (ETR) is used for second or third-line antiretroviral treatment in children with HIV, and a study assessed its outcomes in children across Europe and Thailand.
- Data was collected from 177 children, showing that 69% achieved viral suppression after 12 months and experienced an increase in CD4 cell counts; however, 46% discontinued ETR due to reasons such as treatment simplification and failure.
- Some adverse events were reported, including rare but serious reactions like Stevens-Johnson Syndrome, but overall, ETR proved effective for many treatment-experienced children.