Experiences and challenges of implementing clinical medication reviews in daily practice: a mixed-methods study.

Introduction: Organisational problems still prevent widespread implementation of clinical medication reviews. The Opti-Med2 method was developed to facilitate the process of performing clinical medication reviews. The method includes patient involvement by means of a questionnaire and expert teams of community pharmacists and general practitioners (GPs) to perform pharmacotherapeutic analyses, providing the patients' own GP with pharmacotherapeutic advice.

Improving Access to Adult Hearing Care: A Retrospective Review of an Awareness Campaign and Community Hearing Test Service.

Introduction: Age related hearing loss is in the top ten contributors to the global burden of disease and one of the largest modifiable risk factors for age-related dementia. However, awareness of the consequences of untreated hearing loss is poor and many adults do not seek hearing assessment. Despite World Health Organisation recommendations, no EU country currently has a national adult screening programme.

Eye tracking for the classification of visual function in individuals with vision impairment: A validation in Para athletes.

Eye tracking has the potential to be used as a meaningful measure of the consequences of vision impairment (VI), yet a comprehensive test battery is lacking. In this study, we sought to evaluate the feasibility and validity of a test battery of eye movements as a tool to measure visual performance in individuals with VI. A test battery including fixation stability, smooth pursuit, saccades, free viewing, and visual search was administered to 46 athletes with VI and 10 control participants.

Better movers, better friends? A test for the environmental stress hypothesis in typically developing primary school children.

Relations between children's motor skills and internalizing problems are poorly understood. The environmental stress hypothesis (ESH), originally developed for motor-impaired children, may provide understanding, yet has been scarcely examined in typically developing children. Therefore, we examined: (1) relations between children's motor skills and internalizing problems; (2) the role of secondary stressors, specifically interpersonal conflicts and externalizing problems; and (3) the role of personal resources, namely, prosocial behaviour and social self-efficacy (SSE).

Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [C]DPA713 PET/CT.

Background: Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.

Gender Identity and Gender-Related Medical Outcomes of Autistic Young Adults Who Experienced Transgender Identity as Adolescents.

Purpose: We examined gender identity and gender-affirming care outcomes of autistic transgender adolescents followed into young adulthood, as well as relationships between gender-related medical care receipt and mental health across time.

Methods: This longitudinal two-timepoint study was conducted between 2018 and 2024, with 4 years between timepoints. Twenty-seven autistic transgender youth participated, with one lost to follow-up.

A Unique LHCE Light-Harvesting protein Family is involved in Photosystem I and II Far-Red Absorption in Euglena gracilis.

Photosynthetic organisms have evolved diverse strategies to adapt to fluctuating light conditions, balancing efficient light capture with photoprotection. In green algae and land plants, this involves specialized light-harvesting complexes (LHCs), non-photochemical quenching, and state transitions driven by dynamic remodeling of antenna proteins associated with Photosystems (PS) I and II. Euglena gracilis, a flagellate with a secondary green plastid, represents a distantly related lineage whose light-harvesting regulation remains poorly understood.

A different lens on diagnosis: value of the CFI in asylum seekers' psychiatric diagnostic assessment.

Background: Asylum seekers face significant mental health challenges but underutilise mental health services and are at increased risk of misdiagnosis. The Cultural Formulation Interview (CFI) could be helpful by introducing individuals' culture and context to psychiatric evaluation. However, its impact on the diagnostic process for asylum seekers remains underexplored.

The association between intrinsic capacity and functional ability in older adults - exploring the role of the physical environment.

Background: Ageing in place has been promoted in the Netherlands to encourage optimal functional ability (FA) and independent living among older adults. FA is likely dependent on intrinsic capacity (IC), a composite measure of an individual's mental and physical capacities-and its interaction with the physical environment in which people live. This study aimed to examine the association between IC and FA, as well as to explore how the physical environment may modify this relationship in older adults.

Balancing palliative care needs and medication appropriateness: Initiation and reinitiation of medications at the end of life.

Background: Medications deemed inappropriate and discontinued in the earlier stages of life-limiting disease may become relevant in palliative care context at the end of life. This study aims to determine the incidence of and factors associated with initiation and reinitiation of medications deemed inappropriate according to the STOPPFrail guideline.

Methods: A retrospective cohort study using linked healthcare reimbursement data.

Phenylketonuria: A guide through the complex maze of its neurological pathophysiology providing a new perspective on treatment strategies.

Phenylketonuria (PKU), an autosomal recessive disease caused by a deficiency in the phenylalanine-4-hydroxylase enzyme or its cofactor tetrahydrobiopterin, is characterized by excessive phenylalanine (Phe) and reduced tyrosine (Tyr) levels and typically manifests neurologically. Even early treated PKU patients with proper metabolic control, obtained immediately after birth upon diagnosis of the disease, show late-onset neurological complications. Although the disease has already been researched for over 90 years, the complexity of its neurological pathophysiology has only recently been unraveled.

Attitudes and perceptions of biomedical journal editors in chief towards the use of artificial intelligence chatbots in the scholarly publishing process: a cross-sectional survey.

Background: Artificial intelligence chatbots (AICs) are designed to mimic human conversations through text or speech, offering both opportunities and challenges in scholarly publishing. While journal policies of AICs are becoming more defined, there is still a limited understanding of how Editors in chief (EiCs) of biomedical journals' view these tools. This survey examined EiCs' attitudes and perceptions, highlighting positive aspects, such as language and grammar support, and concerns regarding setup time, training requirements, and ethical considerations towards the use of AICs in the scholarly publishing process.

Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.

The increasing prevalence of overweight/obesity among the elderly has significant implications for oral health due to shared pathophysiological mechanisms. Despite its importance, comprehensive reviews on this topic remain limited. This study investigates the association between overweight/obesity and oral health outcomes in adults aged 55 and older.

Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis.

Introduction: Frailty in older adults impairs Activities of Daily Living (ADL). While exercise interventions improve factors like muscle strength and physical function, their direct impact on ADL ability is inconsistent. This review aims to assess the effectiveness of exercise on ADL ability, identify the most beneficial interventions, and explore mediators.

The effect of human bone morphology on sawing forces.

In orthopaedic surgical procedures, bone cutting is often performed with an oscillating saw. Achieving an optimal cut requires high accuracy, low temperature, minimal surgeon effort, and time efficiency, all of which may be influenced by the forces applied on the sawing device, and the microstructure of the cut bone. The relation between bovine bone microstructure and sawing forces has been studied.

Atypical complications and co-morbidities of type 1 diabetes in young adults.

Aims: Our review aimed to determine the prevalence of - and factors associated with - hearing loss, oral and olfactory disease, frozen shoulder, trigger finger, and hair loss in young adults with type 1 diabetes. These conditions were selected based on research team interests, existing literature, and group discussion.

Methods: We conducted a quantitative narrative review using a systematic process to identify cohort and cross-sectional studies involving young adults with type 1 diabetes (mean age 18-30 years).

Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.

The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (Aβ) distribution (indicating greater hemisphere-specific vulnerability to AD pathology).

Current Practices for Mental Fatigue Quantification and Induction in Movement Science: Introducing the SPeCIFY Guidelines.

Mental fatigue (MF) is a complex phenomenon with significant implications for human performance, for which there are numerous studies investigating the effects of MF. Nevertheless, there is considerable variability in the approaches used to induce and quantify MF, making it hard to compare findings across studies and draw well-supported conclusions. This review addresses the methodological variability in the induction and quantification methods of MF in movement science in the following ways: on the one hand, by providing an overview of task design strategies to induce MF, emphasizing the importance of tailoring task duration, difficulty, and nature to individual participants and specific research contexts; on the other hand, by providing an overview of current methods used to quantify MF, including behavioural, subjective, and physiological measures, and highlighting the strengths and limitations of each.

Clinical outcomes from assisted reproductive technology in predicted hyper-responders: a narrative review.

The management of assisted reproductive technology (ART) in predicted hyper-responders to ovarian stimulation represents a complex and challenging clinical scenario, whereby the benefits of higher oocyte yield must be balanced against the drawbacks and risks of ovarian hyperstimulation syndrome. This review explores advances in ART for hyper-responders, focusing on adapted stimulation protocols, ovulation triggering, cryopreservation, and personalized strategies to optimize outcomes. In-vitro maturation of oocytes, an emerging alternative, is gaining traction for increasing live birth rates in selected cases and expert centers.

A discourse analysis of social inequities, gender, and stigma in tuberculosis policies of seven countries from Africa, Asia, Europe and South America.

Background: Interventions tackling the social aspects of tuberculosis (TB) are widely suggested, yet we miss insights into how policies incorporate these. The language and framing of policies to address TB can lend important insights into how these social drivers are perceived, problematized, and responded to.

Objective: To understand how discourses in current TB policies frame social dimensions of TB, especially concepts of social inequity, gender, and stigma.

Isolation and characterization of bacteriophages from clinical enterohemorrhagic strains.

Temperate bacteriophages play a pivotal role in the biology of their bacterial host. Of particular interest are bacteriophages infecting enterohemorrhagic (EHEC) due to their significant contribution to the pathogenicity of its host, most notably by encoding the key virulence factor of this pathogen, the Shiga toxin. To better understand the role of EHEC phages on the functionality of its host, we isolated eight temperate phages from clinical EHEC isolates and characterized their genomic composition, morphology, and receptor targeting.

Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease.

Vascular diseases are powerful predictors of cardiovascular mortality, but they are typically under-recognized and undertreated. There is no effective treatment for either abdominal aortic aneurysm (AAA) or peripheral artery disease (PAD). Lipids are key molecules in cardiovascular diseases and good candidates for diagnosis, monitoring, and risk prediction; nonetheless, there is very limited information on the lipidomic profile of patients with AAA and PAD.