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Deciphering the proteomic signature of human endometrial receptivity.

Hum Reprod

September 2014

Fundación Instituto Valenciano de Infertilidad (FIVI), Instituto Universitario IVI (IUIVI), Valencia, Spain INCLIVA Biomedical Research Institute, Valencia, Spain

Study Question: Are there any proteomic differences between receptive (R) and non-receptive (NR) endometrial receptivity array (ERA)-diagnosed endometria obtained on the same day of a hormonal replacement therapy (HRT) treatment cycle?

Summary Answer: There is a different proteomic signature between R and NR ERA-diagnosed endometrium obtained on the same day of HRT cycles.

What Is Known Already: The human endometrial transcriptome has been extensively investigated in the last decade resulting in the development of a new diagnostic test based on the transcriptomic signature of the window of implantation (WOI). Much less is known about the proteomics derived from the transcripts present during the WOI.

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