Performance evaluation of a p-type co-axial HPGe detector: Long-term analysis of key parameters for gamma spectroscopy.

Accurate determination of the parameters of each high purity germanium, HPGe detectors ensure the precision of quantitative results obtained from spectrum analysis. This study presents a comprehensive performance evaluation and long-term quality control assessment of a high-purity germanium (HPGe) gamma spectrometry system that has been operational for over 15 years. Key spectrometric measures were recorded, including energy resolution, peak shape ratios, asymmetry, peak-to-Compton ratio, relative efficiency, electronic noise, minimum detectable activity (MDA), and repeatability and reproducibility of the system.

Potassium Hydroxide as a Cost-Effective Catalyst for Broad-Scope Silylation with TMSCF.

The development of efficient and broadly applicable silylation methodologies remains a central goal in synthetic organic and organosilicon chemistry. Traditionally, silylation reactions employ chlorosilanes or hydrosilanes, often necessitating the use of moisture-sensitive and corrosive reagents. Herein, we report a high-yielding, operationally simple, rapid, and economical silylation platform based on trifluoromethyltrimethylsilane (TMSCF) and catalytic potassium hydroxide (KOH).

Health Inequity in People with Cystic Fibrosis: Can We Close the Gap?

Background Although advances in care have improved cystic fibrosis (CF) outcomes in higher-income countries (HICs), the situation remains alarming in lower-income countries (LICs). Methods People with CF (pwCF) enrolled in the European Cystic Fibrosis Society Patient Registry (ECFSPR) and carrying at least one F508del variant allele were evaluated in 2017 and in 2022 for predicted percent forced expiratory volume (ppFEV1), underweight status, and chronic Pseudomonas aeruginosa (Pa) infection, according to the gross national income (GNI) per capita divided into three terciles (low-income countries, LICs; middle-income countries, MICs; and high-income countries, HICs). Survival was evaluated in the periods 2013-2017 and 2018-2022.

Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.

Background: The use of probiotics as a treatment for irritable bowel syndrome (IBS) is gaining attention, with recent studies indicating that certain probiotics or combinations may have mental health benefits for patients with IBS.

Aims: To systematically review and meta-analyze, using network meta-analysis (NWM), the comparative effectiveness and safety of probiotics with psychotropic potential on quality of life, depression, and anxiety in patients with IBS.

Methods: Relevant randomized controlled trials (RCTs) were analyzed, using a Bayesian NWM, to compare the performance of probiotics with mental health benefits in IBS treatment.

Understanding the epidemiology of gastric cancer: a review and case-only analysis from Italy.

Background: Gastric cancer epidemiology evolved rapidly in the last century, shifting from being one of the main causes of cancer-related death to the sixth in high-income countries.

Methods: We conducted a narrative review on gastric cancer epidemiology. Our review focused on trends of gastric cancer and its relationship with Helicobacter pylori infection; cardia and noncardia gastric cancer risk factors; early onset gastric cancer; second primary cancers in patients with gastric cancer; and implementation of gastric cancer prevention strategies.

Enhancing Readability of Lay Abstracts and Summaries for Urologic Oncology Literature Using Generative Artificial Intelligence: BRIDGE-AI 6 Randomized Controlled Trial.

Purpose: To evaluate a generative artificial intelligence (GAI) framework for creating readable lay abstracts and summaries (LASs) of urologic oncology research, while maintaining accuracy, completeness, and clarity, for the purpose of assessing their comprehension and perception among patients and caregivers.

Methods: Forty original abstracts (OAs) on prostate, bladder, kidney, and testis cancers from leading journals were selected. LASs were generated using a free GAI tool, with three versions per abstract for consistency.

Germline Findings From Tumor-Only Comprehensive Genomic Profiling in the RATIONAL Study: A Missed Opportunity?

Purpose: Tumor comprehensive genomic profiling (CGP) may detect potential germline pathogenic/likely pathogenic (P/LP) alterations as secondary findings. We analyzed the frequency of potentially germline variants and large rearrangements (LRs) in the RATIONAL study, an Italian multicenter, observational clinical trial that collects next-generation sequencing-based tumor profiling data, and evaluated how these findings were managed by the enrolling centers.

Patients And Methods: Patients prospectively enrolled in the pathway-B of the RATIONAL study and undergoing CGP with the FoundationOne CDx assays were included in the analysis.

Cycling-Based Telerehabilitation: Acceptability and Feasibility Study.

Background: Telerehabilitation is a promising solution to provide continuity of care. Most existing telerehabilitation platforms focus on rehabilitating upper limbs, balance, and cognitive training, but exercises improving cardiovascular fitness are often neglected.

Objective: The objective of this study is to evaluate the acceptability and feasibility of a telerehabilitation intervention combining cognitive and aerobic exercises.

Novel 3d-printed Coaxial Light Microscope Adapter for Ophthalmic Wet Lab.

Purpose: To compare the usability and training effectiveness of a 3D-printed coaxial illumination system mounted on an off-the-shelf stereo-microscope to a professional ophthalmic surgical microscope, in cataract surgery simulation.

Setting: Ophthalmology Lab, Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

Design: Prospective randomized crossover study.

RETRACTED: Zuccarini et al. Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A Receptor Ligands. 2021, , 3560.

The journal retracts the article titled "Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A Receptor Ligands" [...

Diuretic strategies in acute heart failure: a systematic review and network meta-analysis of randomized clinical trials.

Aims: Several diuretic strategies, including furosemide iv boluses (FB) or continuous infusion (FC), are used in acute heart failure (AHF).

Methods And Results: We systematically searched phase 3 randomized clinical trials (RCTs) evaluating diuretic regimens in admitted AHF patients within 48 hours and irrespective of clinical stabilization. We calculated the odds ratio (OR) of FC or FB plus another diuretic (sequential nephron blockade, SNB) compared to FB alone on 24-hour weight loss (WL) and worsening renal function (WRF), with a random-effects model with inverse variance weighting.

Attosecond All-Optical Retrieval of Valley Polarization via Circular Dichroism in Transient Absorption.

We propose a scheme for retrieving the ultrafast valley polarization (VP) dynamics in two-dimensional hexagonal materials via attosecond circular dichroism (CD) transient absorption spectroscopy. This approach builds on the CD transition between the first and higher conduction bands induced by the circularly polarized probe pulses. The population imbalance at nonequivalent valleys in the first conduction band is proportionally mapped onto the difference in absorption coefficients of two probe pulses with opposite helicities, supporting an unprecedented quantitative retrieval of the corresponding VP dynamics with subfemtosecond time resolution.

Positive Neutrino Masses with DESI DR2 via Matter Conversion to Dark Energy.

The Dark Energy Spectroscopic Instrument (DESI) is a massively parallel spectroscopic survey on the Mayall telescope at Kitt Peak, which has released measurements of baryon acoustic oscillations determined from over 14 million extragalactic targets. We combine DESI Data Release 2 with CMB datasets to search for evidence of matter conversion to dark energy (DE), focusing on a scenario mediated by stellar collapse to cosmologically coupled black holes (CCBHs). In this physical model, which has the same number of free parameters as ΛCDM, DE production is determined by the cosmic star formation rate density (SFRD), allowing for distinct early- and late-time cosmologies.

Core-Periphery Detection in Multilayer Networks.

Multilayer networks provide a powerful framework for modeling complex systems that capture different types of interactions between the same set of entities across multiple layers. Core-periphery detection involves partitioning the nodes of a network into core nodes, which are highly connected across the network, and peripheral nodes, which are densely connected to the core but sparsely connected among themselves. In this paper, we propose a new model of core-periphery structure in multilayer networks and a nonlinear spectral method that simultaneously detects the corresponding core and periphery structures of both nodes and layers in weighted and directed multilayer networks.

Half-Life and Precision Shape Measurement of the 2νββ Decay of ^{130}Te.

We present a new measurement of the 2νββ half-life of ^{130}Te (T_{1/2}^{2ν}) using the first complete model of the CUORE data, based on 1038 kg yr of collected exposure. Thanks to optimized data selection, we achieve a factor of two improvement in precision, obtaining T_{1/2}^{2ν}=(9.32 _{-0.

Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis.

Hepatocyte apoptosis is a key feature of metabolic dysfunction-associated steatohepatitis (MASH), but the fate of apoptotic hepatocytes in MASH is poorly understood. Here, we explore the hypotheses that clearance of dead hepatocytes by liver macrophages (efferocytosis) is impaired in MASH because of low expression of the efferocytosis receptor T cell immunoglobulin and mucin domain containing 4 (TIM4; gene ) by MASH liver macrophages, which then drives liver fibrosis in MASH. We show that apoptotic hepatocytes accumulate in human and experimental MASH, using mice fed the fructose-palmitate-cholesterol (FPC) diet or the high-fat, choline-deficient amino acid-defined (HF-CDAA) diet.

Universal Effective Charges in the sd and fp Shells.

The 247-keV state in ^{54}Sc, populated in the β decay of ^{54}Ca, is reported here as a nanosecond isomer with a half-life of 26.0(22) ns. The state is interpreted as the 1^{+} member of the πf_{7/2}⊗νf_{5/2} spin-coupled multiplet, which decays to the 3^{+},πf_{7/2}⊗νp_{1/2} ground state.

Energy Transfer by Feebly Interacting Particles in Supernovae: The Trapping Regime.

Feebly interacting particles, such as sterile neutrinos, dark photons, and axions, can be abundantly produced in the proto-neutron star (PNS) formed in core-collapse supernovae (CCSNe). These particles can decay into photons or charged leptons, depositing energy outside the PNS. Strong bounds on new particles can thus be derived from the observed luminosity of CCSNe, with even tighter bounds obtained from low-energy SNe observations.

Constraints on Primordial Magnetic Fields from the Lyman-α Forest.

We present the first constraints on primordial magnetic fields from the Lyman-α forest using full cosmological hydrodynamic simulations. At the scales and redshifts probed by the data, the flux power spectrum is extremely sensitive to the extra power induced by primordial magnetic fields in the linear matter power spectrum, at a scale that we parametrize with k_{peak}. We rely on a set of more than a quarter million flux models obtained by varying thermal and reionization histories and cosmological parameters.

Strong Coupling and Dark Modes in the Motion of a Pair of Levitated Nanoparticles.

We experimentally investigate a system composed of two levitating nanospheres whose motions are indirectly coupled via coherent scattering in a single optical cavity mode. The nanospheres are loaded into a double longitudinal tweezer created with two lasers at different wavelengths, where chromatic aberration leads to the formation of two separate trapping sites. We achieve strong coupling between each pair of modes in the transverse plane of the tweezer, and we show the emergence of dark modes in the overall coupled motion.

Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

Excitonic Effects in Phonons: Reshaping the Graphene Kohn Anomalies and Lifetimes.

We develop an ab initio framework that captures the impact of electron-electron and electron-hole interactions on phonon properties. This enables the inclusion of excitonic effects in the optical phonon dispersions and lifetimes of graphene, both near the center (Γ) and at the border (K) of the Brillouin zone, at phonon-momenta relevant for Raman scattering and for the onset of the intrinsic electrical resistivity. Near K, we find a phonon redshift of ∼150  cm^{-1} and a 10× enhancement of the group velocity, together with a 5× increase in linewidths due to a 26× increase of the electron-phonon matrix elements.

Observation of Three Resonant Structures in the Cross Section of e^{+}e^{-}→π^{+}π^{-}h_{c}.

Using e^{+}e^{-} collision data collected with the BESIII detector operating at the Beijing electron positron collider, the cross section of e^{+}e^{-}→π^{+}π^{-}h_{c} is measured at 59 points with center-of-mass energy sqrt[s] ranging from 4.009 to 4.950 GeV with a total integrated luminosity of 22.