Complications of anatomical endoscopic enucleation of the prostate in real-life practice: What we learnt from the 6,193 patients from the Refinement in Endoscopic Anatomical enucleation of Prostate registry.

Introduction: Anatomical endoscopic enucleation of the prostate (AEEP) is a guideline-recommended treatment for benign prostatic hyperplasia (BPH). We aimed to analyze postoperative complications and outcomes within a large real-world database.

Material And Methods: The Refinement in Endoscopic Anatomical enucleation of Prostate (REAP) registry includes patients who received AEEP for BPH in 8 centers worldwide from January 2020 to January 2022.

Software mpMR/US fusion, cognitive, and in-bore biopsy: a comparative analysis of prostate cancer detection.

Introduction: Three MR-targeted biopsy (MR-TB) techniques-software fusion (FUS-TB), cognitive (COG-TB), and in-bore (IB-TB)-are considered comparable by EAU guidelines, although recommendations remain weak. This study aimed to compare detection rates of clinically significant (csPCa), insignificant (cisPCa), and overall prostate cancer (PCa).

Materials And Methods: This prospective, non-randomized, controlled bicentric study (2019-2024) included biopsy-naïve and previously negative biopsy patients with suspected PCa (PSA ≥ 2 ng/mL, TRUS lesion, positive DRE and PI-RADSv2.

Machine learning models to predict postoperative incontinence after endoscopic enucleation of the prostate for benign prostatic hyperplasia: An EAU-Endourology study.

Background: Machine learning (ML) and artificial intelligence (AI) have demonstrated powerful functionality in the healthcare setting thus far. We aimed to construct an AI model to predict postoperative incontinence after enucleation surgery for benign prostatic hyperplasia (BPH).

Methods: Data were taken from two BPH registries and split into training and validation datasets.

Oncologic Outcomes of Template Versus Radioguided Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography Scan: Results from a Multi-institutional Collaboration.

In patients treated with salvage lymph node dissection (sLND) for nodal recurrence of prostate cancer, whether radioguided surgery (RGS) might improve oncologic outcomes as compared with template sLND remains unknown. This study included 259 patients who experienced a prostate-specific antigen (PSA) rise and nodal-only recurrence after radical prostatectomy and underwent pelvic sLND at 11 tertiary referral centers between 2012 and 2022. Lymph node recurrence was documented by prostate-specific membrane antigen positron emission tomography scans.

Optilume, a minimally invasive solution for BPH and urethral stricture: what we know, what we need? an EAU endourology scoping review.

Introduction: Optilume and Optilume BPH, a minimally invasive drug-coated balloon (DCB) combining mechanical dilation with paclitaxel delivery, offers a novel approach for treating urethral strictures and benign prostatic hyperplasia (BPH) respectively. This scoping review summarizes current evidence on their efficacy, safety, and long-term outcomes to evaluate their role in reducing recurrence and improving patient-reported and functional outcomes.

Methods: Following PRISMA guidelines, a systematic search (Embase, PubMed, Cochrane, Scopus) until March 2025 identified 287 studies.

Acute Kidney Injury in a Cancer Patient Exposed to Relugolix and Abiraterone.

Introduction: Abiraterone acetate is an inhibitor of androgen biosynthesis and is approved as a treatment for metastatic castration-resistant and metastatic castration-sensitive prostate cancer. Neither relugolix nor abiraterone is known to cause acute kidney injury (AKI).

Case Presentation: A 72-year-old Caucasian man with metastatic prostate cancer presented with non-oliguric severe AKI 1 week after receiving simultaneous therapy with relugolix and abiraterone.

An evidence gap map of the personalized medicine in bladder cancer.

Objective: The study aims to develop an Evidence Gap Map (EGM) to summarize the current evidence cited in personalized medicine (PM) in bladder cancer, focusing on systematic reviews and high-level evidence syntheses.

Methods: The review involved a comprehensive search in databases up to June 2024, and involved a two-phase analysis, using data from PubMed for scientometric analysis and R Studio with the Biblioshiny tool for co-occurring word network analysis.

Results: After filtering out irrelevant articles, the selection was narrowed to 3,705 items.

The Role of mA-RNA Methylation in the Development, Progression, and Treatment Response of Bladder Cancer.

Bladder cancer (BCa) remains a significant clinical challenge because of high recurrence rates and variable response to immunotherapy and chemotherapy. Recent studies have highlighted the role of N6-methyladenosine (mA) modification in RNA in the regulation of various cellular processes, including tumor progression and drug resistance. The review examines the impact of mA methylation on BCa pathogenesis, with a particular special focus on the role of mA pathway factors and mA-modified RNAs in tumorigenesis, proliferation, invasion, and migration of cancer cells.

Modeling of phosphorylated forms of complement system factors C4 and CFB.

Kidney cancer ranks as the 14th most common cancer worldwide. Despite its heterogeneity, it often presents with clinical manifestations similar to other renal diseases, which complicates timely diagnosis. Many types of malignant renal neoplasms can mimic benign processes, and some tumors can develop asymptomatically until the late stages of the disease.

Assessing Urinary Microbiota in Chronic Cystitis Based on Midstream Urine Sample.

Introduction: This study aimed to compare the urinary microbiota of healthy women, women with a predisposition to UTIs, and patients with chronic recurrent cystitis using real-time PCR, as well as identify diagnostic markers for urinary diseases.

Methods: The study enrolled 3 groups of patients: a healthy control group, patients with chronic recurrent cystitis, and patients with a risk of developing UTIs. Urine samples were analyzed by multiplex real-time PCR reagent kits Femoflor®16 and BacScreen OM.

Impact of suction ureteral access sheath in ureteroscopy/retrograde intrarenal surgery: a systematic review and meta-analysis.

Background: Advances in technology have led to the introduction of the suction ureteral access sheaths (SUASs) in ureteroscopy (URS) and retrograde intrarenal surgery (RIRS), with their clinical benefits becoming widely acknowledged. We aimed to evaluate the efficacy and safety of using SUASs during URS and RIRS.

Methods: A systematic search was conducted in April 2024 across the MEDLINE, Scopus, and Web of Science databases.

Urinary Outcomes of Minimally Invasive Treatments for Prostate Cancer-A Systematic Review by Young Academic Urologists' Urotechnology Working Group.

Minimally invasive treatments (MITs) have emerged as viable treatment options for carefully selected patients with localized disease. Their major advantage is that MITs enable the preservation of nearby healthy prostate tissue and critical structures such as the urethral sphincter and neurovascular bundles without compromising oncologic outcomes. The aim of the current review is to describe the impact of different MITs for prostate cancer (PCa) on urinary continence.

GPT-4 generates accurate and readable patient education materials aligned with current oncological guidelines: A randomized assessment.

Introduction And Aim: Guideline-based patient educational materials (PEMs) empower patients and reduce misinformation, but require frequent updates and must be adapted to the readability level of patients. The aim is to assess whether generative artificial intelligence (GenAI) can provide readable, accurate, and up-to-date PEMs that can be subsequently translated into multiple languages for broad dissemination.

Study Design And Methods: The European Association of Urology (EAU) guidelines for prostate, bladder, kidney, and testicular cancer were used as the knowledge base for GPT-4 to generate PEMs.

Endoscopic enucleation of the prostate in men aged 80 years and older. Outcomes from a global, large, and multicenter series using different energy sources and techniques.

Purpose: To provide the outcomes from a multicentric series of men aged 80 years and above, understand the feasibility of endoscopic enucleation of the prostate (EEP), and compare different energy sources and techniques.

Methods: We extracted data on patients who underwent EEP in 15 Centers (January 2019-January 2023). Continuous variables are expressed as medians and interquartile ranges while categorical variables as absolute numbers and percentages.

Application of CPB in surgery for extended tumor thrombosis of inferior vena cava and right atrium.

Objective: To research the best time to provide cardiopulmonary bypass (CPB) and the best way to do it when treating an extensive tumor thrombosis of the inferior vena cava vein (IVC).

Results: The operating times in groups A and B were (376.7 ± 91.

Perioperative morbidity of open retroperitoneal lymph node dissection for testicular germ cell tumors: an in-depth single center analysis according to European Association of Urology guidelines of complication reporting and a scoping literature review.

Introduction: Retroperitoneal lymph node dissection (RPLND) is crucial in managing metastatic germ cell tumors (GCTs), particularly post-chemotherapy. Given the long-term survival of these patients, perioperative morbidity is a significant concern. However, data on RPLND morbidity using predefined reporting standards are scarce.

[Postoperative stress urinary incontinence in patients after various techniques of laser enucleation for benign prostatic hyperplasia].

Aim: To compare the incidence of postoperative stress urinary incontinence (SUI) in patients with benign prostatic hyperplasia after three different techniques of thulium fiber laser prostate enucleation (ThuFLEP): two-lobe, enucleation of all lobes in a single block (en-bloc) and enucleation of all lobes in a single block without additional longitudinal incisions (total en-bloc).

Materials And Methods: A retrospective and prospective comparative analysis included 472 patients, who were undergone to three different techniques of ThuFLEP. The surgical interventions were performed by three experienced surgeons from January 2015 to May 2023.

[Recurrent stress urinary incontinence in women: results of surgical reinterventions].

Background: The efficiency of surgical treatment of stress urinary incontinence (SUI) in women is 77-85%, and in nearly 15% of cases repeated procedures are required.

Aim: To present the experience of our center in the treatment of recurrent SUI in women and to evaluate the efficiency of repeated interventions.

Materials And Methods: The retrospective study included women with recurrent SUI.

[Comparison of extended-release sildenafil with standard sildenafil in a randomized placebo-controlled study].

Introduction: Sildenafil citrate (Viagra) is widely used to treat erectile dysfunction (ED). However, this drug is associated with high frequency of adverse events such as headaches and cardiovascular disorders. "Vildegra" is a sildenafil encapsulated in hypromellose, which provides a slow release of the substance and a longer duration of action (13 hours vs.

[Development of a Deep Learning-Based System for Supporting Medical Decision-Making in PI-RADS Score Determination].

Aim: to explore the development of a computer-aided diagnosis (CAD) system based on deep learning (DL) neural networks aimed at minimizing human error in PI-RADS grading and supporting medical decision-making.

Materials And Methods: This retrospective multicenter study included a cohort of 136 patients, comprising 108 cases of PCa (PI-RADS score 4-5) and 28 cases of benign conditions (PI-RADS score 1-2). The 3D U-Net architecture was applied to process T2-weighted images (T2W), diffusion-weighted images (DWI), and dynamic contrast-enhanced images (DCE).

Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis.

Background: Immune checkpoint inhibitors (ICI) and chemotherapy, including antibody-drug conjugates, are widely used for the treatment of patients with advanced unresectable or metastatic urothelial carcinoma (UC). The majority of elderly patients receive concomitant medications to address various comorbidities. We aimed to evaluate the impact of concomitant medications on oncological outcomes in patients with advanced unresectable or metastatic UC treated with systemic therapy.

Erectile dysfunction in railway station workers: A randomized study of different treatment approaches.

Introduction: The profession of a locomotive engineer involves stress, lack of adequate sleep and rest, and a sedentary lifestyle, all of which can contribute to the development of erectile dysfunction (ErD) as well as arterial hypertension.

Materials And Methods: Consecutive patients of the railway hospital in Barnaul with arterial hypertension aged 30-60 who work as machinists or assistant locomotive drivers were enrolled. Those who have symptoms of ErD were randomized into three groups: group 1 received an endogenous nitric oxide-synthase (NOS) activator, group 2 received a combination of endogenous NOS activator and phosphodiesterase type 5 inhibitor (PDE-5i), and group 3 received no additional treatment for ErD.

A Systematic Review and Meta-Analysis of Penis Length and Circumference According to WHO Regions: Who has the Biggest One?

Objective: This study aimed to perform a systematic review and meta-analysis of stretched, erect, and flaccid penis length as well as circumference according to geographic WHO regions.

Methods: PubMed, Embase, Scopus, and Cochrane Library were searched for articles published until February 2024. Studies in which a healthcare professional evaluated the penis size were considered eligible.

Awareness and use of generative AI-powered tools: results of one-year follow-up prospective cross-sectional global survey.

Background: Generative AI (GenAI) frameworks, such as generative pre-trained transformer (GPTs) and large language models (LLMs), promise to transform clinical and research practices. Informed human opinion is key to guiding appropriate technological development and task refinement. Detailed data on how GPTs/LLMs powered-Chatbots usage, perceived risks and benefits among physicians has evolved over time and their impact on clinical and academic activities remain unclear.