Engineering Extracellular Matrix-Bound Nanovesicles Secreted by Three-Dimensional Human Mesenchymal Stem Cells.

Extracellular matrix (ECM) in the human tissue contains vesicles, which are defined as matrix-bound nanovesicles (MBVs). MBVs serve as one of the functional components in ECM, recapitulating part of the regulatory roles and in vivo microenvironment. In this study, extracellular vesicles from culture supernatants (SuEVs) and MBVs are isolated from the conditioned medium or ECM, respectively, of 3D human mesenchymal stem cells.

Imaging quantized vortex rings in superfluid helium to evaluate quantum dissipation.

The motion of quantized vortices is responsible for many intriguing phenomena in diverse quantum-fluid systems. Having a theoretical model to reliably predict the vortex motion therefore promises a broad significance. But a grand challenge in developing such a model is to evaluate the dissipative force caused by thermal quasiparticles in the quantum fluids scattering off the vortex cores.

Cavitation Rheology of Model Yield Stress Fluids Based on Carbopol.

Measuring the surface tension of yield stress fluids has remained a critical challenge due to limitations of the traditional tensiometry techniques. Here, we overcome those limits and successfully measure the surface tension and mechanical properties of a model yield stress fluid based on Carbopol gels via a needle-induced cavitation (NIC) technique. Our results indicate that the surface tension is approximately 70 ± 3 mN/m, and is independent of the rheology of yield stress fluid over a wide range of yield stress values σ = 0.

Osmotically Rupturing Phagosomes in Macrophages Using PNIPAM Microparticles.

The rupture of macrophage phagosomes has been implicated in various human diseases and plays a critical role in immunity. However, the mechanisms underlying this process are complex and not yet fully understood. This study describes the development of a robust engineering method for rupturing phagosomes based on a well-defined mechanism.

Inflammatory Response and Exosome Biogenesis of Choroid Plexus Organoids Derived from Human Pluripotent Stem Cells.

The choroid plexus (ChP) is a complex structure in the human brain that is responsible for the secretion of cerebrospinal fluid (CSF) and forming the blood-CSF barrier (B-CSF-B). Human-induced pluripotent stem cells (hiPSCs) have shown promising results in the formation of brain organoids in vitro; however, very few studies to date have generated ChP organoids. In particular, no study has assessed the inflammatory response and the extracellular vesicle (EV) biogenesis of hiPSC-derived ChP organoids.

Effects of rainfall characteristics on runoff quality parameters within an industrial sector in Tennessee, USA.

The relationship between rainfall characteristics and pollutant discharge has rarely been investigated in industrial sectors. To address this need, we investigated the pollutant concentrations of surface runoff and the correlation between pollutant discharge and rainfall characteristics using the self-reported stormwater quality data collected under the Tennessee Multi-Sector Permit program for two industrial facilities in West Tennessee. The variation of certain stormwater quality parameters over this period was utilized as an indicator to evaluate the effectiveness of control measures implemented at these two facilities.

A Review of Skin-Wearable Sensors for Non-Invasive Health Monitoring Applications.

The early detection of fatal diseases is crucial for medical diagnostics and treatment, both of which benefit the individual and society. Portable devices, such as thermometers and blood pressure monitors, and large instruments, such as computed tomography (CT) and X-ray scanners, have already been implemented to collect health-related information. However, collecting health information using conventional medical equipment at home or in a hospital can be inefficient and can potentially affect the timeliness of treatment.

Probing self-assembled micellar topologies via micro-scale diffusive dynamics of surfactants.

Hypothesis: Surfactants spontaneously self-assemble in aqueous solutions and are critical in energy, biotechnology, and the environment. The self-assembled micelles may experience distinct topological transitions beyond a critical counter-ion concentration, yet the associated mechanical signatures are identical. By monitoring self-diffusion dynamics of individual surfactants in micelles via a non-invasive H NMR diffusometry, we may distinguish various topological transitions overcoming challenges associated with traditional microstructural probing techniques.

A survey of multi-criteria decision-making techniques for green logistics and low-carbon transportation systems.

With the increasing severity of environmental problems, low-carbon development has become an inevitable choice. Nowadays, low-carbon green sustainable development is influenced by a variety of factors such as social, environmental, technological, and economic development levels, making its development complex, which in turn imposes challenges on decision-makers. In this context, the application of multi-criteria decision-making (MCDM) in different areas of sustainable development engineering has become a hot topic.

Helical Locomotion in Yield Stress Fluids.

We report three stages for locomotion of a helical swimmer in yield stress fluids. In the first stage, the swimmer must overcome the material's yield strain to generate rotational motion. However, exceeding the first threshold is not sufficient for locomotion.

Low-temperature torrefaction assisted with solid-state KOH/urea pretreatment for accelerated methane production in wheat straw anaerobic digestion.

Low-temperature torrefaction assisted with solid-state KOH/urea applied onto wheat straw was proposed to break down the lignocellulosic material to enhance biomethane production in anaerobic digestion (AD). The optimization of key parameters applying the Box-Behnken design and response surface methodology showed that an addition of 0.1 g/g KOH/urea at 180 °C while torrefying for 30 min was the optimal condition for producing biomethane.

Vanadium MXenes materials for next-generation energy storage devices.

Batteries and supercapacitors have emerged as promising candidates for next-generation energy storage technologies. The rapid development of new two-dimensional (2D) electrode materials indicates a new era in energy storage devices. MXenes are a new type of layered 2D transition metal carbides, nitrides, or carbonitrides that have drawn much attention because of their excellent electrical conductivity, electrochemical and hydrophilic properties, large surface area, and attractive topological structure.

Near-wall vortical structures in domains with and without curved surfaces.

Taylor-Couette flow is a canonical flow to study Taylor-Görtler (TG) instability or centrifugal instability and the associated vortices. TG instability has been traditionally associated with flow over curved surfaces or geometries. In the computational study, we confirm the presence of TG-like near-wall vortical structures in two lid-driven flow systems, the Vogel-Escudier (VE) and the lid-driven cavity (LDC) flows.

Degradation of per- and polyfluoroalkyl substances in landfill leachate by a thin-water-film nonthermal plasma reactor.

Per- and polyfluoroalkyl substances (PFAS) are present in landfill leachate, posing potential challenges to leachate disposal and treatment. This work represents the first study of a thin-water-film nonthermal plasma reactor for PFAS degradation in landfill leachate. Of the 30 PFAS measured in three raw leachates, 21 were above the detection limits.

Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells.

Brain cancer is a group of diverse and rapidly growing malignancies that originate in the central nervous system (CNS) and have a poor prognosis. The complexity of brain structure and function makes brain cancer modeling extremely difficult, limiting pathological studies and therapeutic developments. Advancements in human pluripotent stem cell technology have opened a window of opportunity for brain cancer modeling, providing a wealth of customizable methods to simulate the disease in vitro.

Covalently Attached Slippery Surface Coatings to Reduce Protein Adsorptions on Poly(dimethylsiloxane) Planar Surfaces and 3D Microfluidic Channels.

Silicone elastomers, such as poly(dimethylsiloxane) (PDMS), have a broad range of applications in basic biomedical research and clinical medicine, ranging from the preparation of microfluidic devices for organs-on-chips and ventriculoperitoneal shunts for the treatment of hydrocephalus to implantable neural probes for neuropharmacology. Despite the importance, the protein adsorptions on silicone elastomers in these application environments represent a significant challenge. Surface coatings with slippery lubricants, inspired by the pitcher plants, have recently received much attention for reducing protein adsorptions.

High-Sensitivity Low-Energy Ion Spectroscopy with Sub-Nanometer Depth Resolution Reveals Oxidation Resistance of MoS Increases with Film Density and Shear-Induced Nanostructural Modifications of the Surface.

For decades, density has been attributed as a critical aspect of the structure of sputter-deposited nanocrystalline molybdenum disulfide (MoS) coatings impacting oxidation resistance and wear resistance. Despite its importance, there are few examples in the literature that explicitly investigate the relationship between the density and oxidation behaviors of MoS coatings. Aging and oxidation are primary considerations for the use of MoS coatings in aerospace applications as they inevitably experience prolonged storage in water and oxygen-rich environments prior to use.

Combined Additive and Laser-Induced Processing of Functional Structures for Monitoring under Deformation.

This research introduces a readily available and non-chemical combinatorial production approach, known as the laser-induced writing process, to achieve laser-processed conductive graphene traces. The laser-induced graphene (LIG) structure and properties can be improved by adjusting the laser conditions and printing parameters. This method demonstrates the ability of laser-induced graphene (LIG) to overcome the electrothermal issues encountered in electronic devices.

Memory in aging colloidal gels with time-varying attraction.

We report a combined rheology, x-ray photon correlation spectroscopy, and modeling study of gel formation and aging in suspensions of nanocolloidal spheres with volume fractions of 0.20 and 0.43 and with a short-range attraction whose strength is tuned by changing temperature.

Effect of Interface Modification on Mechanoluminescence-Inorganic Perovskite Impact Sensors.

It is becoming increasingly important to develop innovative self-powered, low-cost, and flexible sensors with the potential for structural health monitoring (SHM) applications. The mechanoluminescence (ML)-perovskite sensor is a potential candidate that combines the light-emitting principles of mechanoluminescence with the light-absorbing properties of perovskite materials. Continuous in-situ SHM with embedded sensors necessitates long-term stability.

Polymer-derived SiOC reinforced with core-shell nanophase structure of ZrB/ZrO for excellent and stable high-temperature microwave absorption (up to 900 °C).

Microwave absorbing materials for high-temperature harsh environments are highly desirable for aerodynamically heated parts and engine combustion induced hot spots of aircrafts. This study reports ceramic composites with excellent and stable high-temperature microwave absorption in air, which are made of polymer-derived SiOC reinforced with core-shell nanophase structure of ZrB/ZrO. The fabricated ceramic composites have a crystallized t-ZrO interface between ZrB and SiOC domains.

A Review of Challenges and Opportunities for Microbially Removing 1,4-Dioxane to Meet Drinking-Water and Groundwater Guidelines.

1,4-Dioxane is an emerging contaminant in drinking-water sources and contaminated sites. Microbial removal of 1,4-dioxane has attracted a lot of attention, but faces a challenge: being not able to continuously metabolize 1,4-dioxane to below most drinking-water and groundwater guidelines. The 1,4-dioxane concentrations in most drinking-water sources and contaminated sites are too low to sustain biomass growth.

Assessing Nontrivial Topology in Weyl Semimetals by Dichroic Photoemission.

The electronic structure of Weyl semimetals features Berry flux monopoles in the bulk and Fermi arcs at the surface. While angle-resolved photoelectron spectroscopy (ARPES) is successfully used to map the bulk and surface bands, it remains a challenge to explicitly resolve and pinpoint these topological features. Here we combine state-of-the-art photoemission theory and experiments over a wide range of excitation energies for the Weyl semimetals TaAs and TaP.