Malignancy classification of thyroid incidentalomas using 18F-fluorodeoxy-d-glucose PET/computed tomography-derived radiomics.

Background: Thyroid incidentalomas (TIs) are incidental thyroid lesions detected on fluorodeoxy-d-glucose (18F-FDG) PET/computed tomography (PET/CT) scans. This study aims to investigate the role of noninvasive PET/CT-derived radiomic features in characterizing 18F-FDG PET/CT TIs and distinguishing benign from malignant thyroid lesions in oncological patients.

Materials And Methods: We included 46 patients with PET/CT TIs who underwent thyroid ultrasound and thyroid surgery at our oncological referral hospital.

The Qaly study: Quality of life and lower extremity lymphedema in 174 patients after inguinal lymphadenectomy.

Background: Lower extremity lymphedema (LEL) can develop in patients who undergo inguinal lymph node dissection (ILND) in the treatment of gynecologic, genitourinary, and skin and soft tissue malignancies. While LEL can negatively impact quality of life, the poorly documented prevalence and severity of lymphedema-related symptoms complicates the ability to identify high-risk patients and improve the selection of candidates for emerging microsurgical interventions.

Methods: This multicenter, cross-sectional study included patients who underwent ILND between 1990 and 2022 across three medical centers in the Netherlands.

Cancer outcomes in women without upfront surgery for ductal carcinoma in situ: observational cohort study.

Objective: To determine the risk of subsequent ipsilateral invasive breast cancer in women who do not receive upfront surgery on diagnosis of ductal carcinoma in situ (DCIS).

Design: Observational cohort study using data abstracted directly from patients' medical records and from a national cancer registry in patients with primary DCIS diagnosed between 2008 and 2015.

Setting: Commission on Cancer accredited facilities (n=1330) in the US.

Increased incidence of primary metastatic prostate cancer in the era of PSMA PET/CT: a population-based analysis.

Purpose: To evaluate the effects of prostate-specific membrane antigen (PSMA) PET/CT use for primary staging on nationwide stage-specific prostate cancer (PCa) incidence rates and treatment patterns.

Methods: For this population-based cohort study, all men diagnosed with PCa in the Netherlands from 2010 to 2023 were identified in the Netherlands Cancer Registry. Year of diagnosis was used as proxy measure for PSMA PET/CT availability and use for primary staging.

Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer.

Importance: Etiologic heterogeneity in breast carcinogenesis needs to be well characterized for targeted prevention. Associations between menopausal hormonal therapy (MHT) and oral contraceptive (OC) use and breast cancer intrinsic-like subtypes are not well understood.

Objective: To examine whether exogenous hormone use is differentially associated with breast cancer subtypes and to evaluate heterogeneity by intrinsic-like subtypes.

Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer.

Aim: We previously published selection criteria for proton therapy (PT) in the Netherlands for breast cancer (BC) and thoracic lymphoma patients, based upon the Absolute Excess Risk (AER) for acute coronary events. The aim of the current paper was to define additional criteria to select BC and thoracic lymphoma patients for PT, to reduce the risk of second primary BC and lung cancer (LC).

Methods: Based on a literature review, we identified Excess Relative Risks (ERR)/Gy mean organ dose of second primary BC and LC, for selected patient groups.

TRIP12's role in the governance of DNA polymerase β involvement in DNA damage response and repair.

The multitude of DNA lesion types, and the nuclear dynamic context in which they occur, presents a challenge for genome integrity maintenance as this requires the engagement of different DNA repair pathways. Specific "repair controllers" that facilitate DNA repair pathway crosstalk between double-strand break (DSB) repair and base excision repair (BER) and that regulate BER protein engagement at lesion sites have yet to be identified. Here, we find that DNA polymerase β (Polβ), crucial for BER, is ubiquitylated in a BER complex-dependent manner by TRIP12, an E3 ligase that partners with UBR5 to restrain DSB repair signaling.

Granulosa cell tumor patients presenting with acute abdomen: a case series.

Objective: To highlight the unique clinical presentation of acute abdomen in granulosa cell tumor patients.

Methods: In a multicenter cohort study of adult-type granulosa cell tumors, women presenting with an acute abdomen at diagnosis were identified (Brink, 2025). After informed consent, clinical data were retrieved from patient records and collected in a Castor EDC database.

The role of primary tumour site surgery in metastatic UTUC: a systematic review and meta-analysis.

Objective: To assess the impact of primary tumour surgery on survival outcomes in patients with metastatic upper urinary tract urothelial carcinoma (mUTUC) by conducting a systematic review and meta-analysis.

Methods: A systematic search was conducted using the PubMed/Medline, Embase, Web of Science, and Cochrane Library databases for studies published up to January 2025, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible studies included adult patients (≥18 years) diagnosed with mUTUC (cM+ excluding cN + M0).

AI-based CT assessment of 3117 vertebrae reveals significant sex-specific vertebral height differences.

Predicting vertebral height is complex due to individual factors. AI-based medical imaging analysis offers new opportunities for vertebral assessment. Thereby, these novel methods may contribute to sex-adapted nomograms and vertebral height prediction models, aiding in diagnosing spinal conditions like compression fractures and supporting individualized, sex-specific medicine.

Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs.

Purpose: This study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors.

Methods: Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators.

Renal clearance of fluorescent agents can compromise image-guided surgery along the urinary tract.

Objectives: To study the effect of renally cleared fluorescent agents on image-guided surgery along the urinary tract by using the renally cleared, non-tumour-specific, fluorescent dye fluorescein.

Subjects And Methods: Sixteen patients who underwent robot-assisted radical prostatectomy (RARP) with lymph node dissection received an intradermal injection of fluorescein. The slow-release of the fluorescein from the skin into the lymph- and bloodstream were used as a pharmacokinetic model for slow release from receptor-targeted agents.

Patritumab Deruxtecan (HER3-DXd; MK-1022) in Non-Small Cell Lung Cancer After Platinum-Based Chemotherapy and Immunotherapy.

Purpose: Patritumab deruxtecan (HER3-DXd; MK-1022) is an investigational HER3-directed antibody-drug conjugate composed of a human immunoglobulin G1 monoclonal antibody to HER3 (patritumab) covalently linked via a stable tetrapeptide-based cleavable linker to a topoisomerase I inhibitor payload that has shown durable antitumor activity in previously treated patients with -mutated advanced non-small cell lung cancer (NSCLC). We extend these observations to patients with advanced NSCLC with other/no identified driver genomic alterations.

Methods: Patients with advanced squamous or nonsquamous NSCLC without a common -activating mutation whose disease had progressed on previous therapies including platinum-based chemotherapy, immune checkpoint inhibitors, and targeted therapy (for patients with known actionable genomic alterations) received HER3-DXd 5.

The bibliography of Rudolf Nieuwenhuys.

This comprehensive bibliography of Rudolf Nieuwenhuys's publications accompanies the multi-authored eulogy: Rudolf Nieuwenhuys (11 June 1927-4 November 2024): a scholarly life (Bakker et al. 2025, https://doi.org/10.

Prognostic Role of Serum IL-6 Levels in Bladder Cancer Patients and Hints of its Origin.

Background: Interleukin-6 (IL-6) is associated with adverse clinical outcome in cancer patients. In bladder cancer (BC) patients, higher IL-6 serum levels have been linked with adverse pathologic features, worse overall survival (OS) and cancer-specific survival (CSS). IL-6 is being investigated as a therapeutic target.

Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis.

The biological mechanisms underlying the cooperation between germline genetic variants and somatic mutations during carcinogenesis are rarely elucidated. Here, characterizing isogenic prostate cancer cell lines, we dissected the interplay between a germline variant at the 7p14.3 locus (rs1376350, G>A) and early recurrent prostate cancer-specific mutation in the Speckle-Type POZ protein (SPOP) gene across human prostate adenocarcinomas.

Biomarker analysis and treatment dynamics following preoperative ipilimumab plus nivolumab in locally advanced urothelial cancer from the phase 1B NABUCCO study.

Purpose: In NABUCCO, safety and efficacy of preoperative ipilimumab plus nivolumab were assessed in stage III urothelial cancer. Encouraging responses were achieved and ipilimumab 3 mg/kg (ipilimumab-high) appeared more effective than ipilimumab 1 mg/kg (ipilimumab-low). We explored ipilimumab plus nivolumab response biomarkers and tumor micro environment (TME) treatment dynamics.

Treatment decisions for intermediate-sized brain metastases in or near the motor cortex among the neuro-oncology community.

Purpose: Currently, there is lack of consensus regarding the optimal treatment strategy (surgery versus radiotherapy) for intermediate-sized (2-4 cm) brain metastases (BM), especially those located in or near the motor cortex. This survey aims to gain insight into treatment decisions for these BM among the Dutch multidisciplinary neuro-oncology community.

Methods: An electronic survey was distributed among neurosurgeons, radiation oncologists, neurologists, and medical oncologists in The Netherlands.

A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability.

This independent crossover study assessed curcumin bioavailability and excretion in nine healthy males receiving three formulations (AOV, Longvida, and NovaSOL) at about 570 mg, while AOV was also tested at 2280 mg, with and without piperine. Plasma levels of unconjugated curcumin remained below 2 nM in most cases, including high-dose AOV and piperine combinations. NovaSOL achieved the highest levels (6.

Rudolf Nieuwenhuys (11 June 1927-4 November 2024): a scholarly life.

This collective eulogy by colleagues, co-authors and friends is a tribute to the work and life of Rudolf Nieuwenhuys. 'Neurofascination' is an apt label for his scholarly life in the sciences from the start in 1955 until his last days in 2024. In addition, he had a broad interest in Roman and Gothic architecture, the history and politics of the twentieth century, religion and the music of Johann Sebastian Bach.

Quality Indicators for Renal Cancer Care: A Systematic Review.

Background And Objective: Quality indicators (QIs) are crucial for evaluating health care delivery, including effectiveness, safety, and patient-centered outcomes. In contrast to other fields, the definition and implementation of QIs for renal cell carcinoma (RCC) present distinct challenges and remain unmet needs. We summarized the available data on QIs for RCC, focusing on their characterization throughout the care pathway and the potential areas for further development.

Optimal follow-up strategy using high-risk human papillomavirus testing and cytology after conservative treatment for cervical adenocarcinoma in situ.

Background: After treatment for cervical adenocarcinoma in situ, patients remain a risk for recurrent adenocarcinoma in situ, cervical intraepithelial grade 3, or cervical cancer.

Objective: This study aimed to determine the optimal follow-up strategy for high-risk human papillomavirus and cytology testing in conservatively treated patients with adenocarcinoma in situ.

Study Design: Patients were selected from a nationwide, retrospective cohort that included pathology reports from the Dutch Nationwide Pathology Databank (Palga) and survival data from the Central Bureau for Genealogy for patients conservatively treated for adenocarcinoma in situ between 1990 and 2021.

Post-processing steps improve generalisability and robustness of an MRI-based radiogenomic model for human papillomavirus status prediction in oropharyngeal cancer.

Objectives: To assess the impact of image post-processing steps on the generalisability of MRI-based radiogenomic models. Using a human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) prediction model, this study examines the potential of different post-processing strategies to increase its generalisability across data from different centres and image acquisition protocols.

Materials And Methods: Contrast-enhanced T1-weighted MR images of OPSCC patients of two cohorts from different centres, with confirmed HPV status, were manually segmented.