Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Small extracellular vesicles (sEVs) hold significant promise for targeted drug delivery, owing to their unique ability to target and accumulate in specific tissues. The organotropism of sEVs is primarily determined by the presence of integrins on their surface. In this study, sEV with enriched integrin β4, designated as XP-ITGβ4-sEV, are engineered to enhance lung-targeting capabilities. The therapeutic efficacy of doxorubicin-loaded XP-ITGβ4-sEV (XP-ITGβ4-sEV/Dox) is evaluated in targeting pulmonary metastasis of advanced hepatocellular carcinoma (HCC) using a murine lung metastasis model. Remarkably, treatment with XP-ITGβ4-sEV/Dox effectively suppresses tumor cell colonization in the lungs compared to an equivalent dose of free doxorubicin. Histological analyses reveal a reduction in lung metastatic foci, inhibition of proliferation, and an increase in apoptosis of HCC cells. Notably, XP-ITGβ4-sEV/Dox exhibits a superior therapeutic efficacy with an improved safety profile compared to a higher dose of free doxorubicin that demonstrates similar efficacy. These findings collectively underscore the potential of integrin β4-enriched sEVs as a targeted drug delivery system for addressing pulmonary metastasis of HCC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adhm.202502649 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Understanding the complexities of oral healthcare delivery in correctional settings: a qualitative exploration of barriers, facilitators, and opportunities.
BMC Public Health
September 2025
Heidelberg Institute of Global Health, Heidelberg University, Bergheimer Str. 20, Zimmer 317, 69115, Heidelberg, Germany.
Background: People living in prison face exceptionally high prevalence rates of tooth decay, periodontal disease, and poor oral health-related quality of life. Despite its importance, various aspects of oral healthcare in prison settings remain understudied. The present study investigates the barriers and facilitators associated with providing and utilizing oral health services in prison settings, drawing on insights from prison health experts, managerial and custodial staff, healthcare providers, and individuals with lived experience of imprisonment.
View Article and Find Full Text PDFAntitumor Effects of Doxorubicin-Loaded Cellulose Nanoparticles in the Rabbit VX2 Liver Tumor Model.
Cardiovasc Intervent Radiol
September 2025
Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
Purpose: To evaluate the preclinical efficacy and safety of transarterial chemoembolization (TACE) using doxorubicin-loaded biocompatible cellulose nanoparticles in a rabbit VX2 liver tumor model.
Materials And Methods: Following institutional animal care committee approval, 23 rabbits with VX2 liver tumors were randomized into three groups: Group A (n = 9) received doxorubicin-loaded cellulose nanoparticles with ethiodized oil; Group B (n = 9) received doxorubicin with ethiodized oil; and Group C (n = 5) served as untreated controls. Tumor size was monitored via ultrasound for 4 weeks, and serum liver enzymes (aspartate transaminase and alanine transaminase) were measured on days 1, 3, and 7 to assess hepatotoxicity.
A numerical investigation of the kinematic and fluid dynamic behaviour of an intramuscular autoinjector designed for optimising injection efficiency.
Med Eng Phys
October 2025
Department of Mechanical Engineering, University of Cape Town, 7701, South Africa; Centre for Research in Computational and Applied Mechanics (CERECAM), University of Cape Town, 7701, South Africa.
The usability and versatility of autoinjectors in managing chronic and autoimmune diseases have made them increasingly attractive in medicine. However, investigations into autoinjector designs require an understanding of the kinematic properties and fluid behaviour during injection. To optimise injection efficiency, this study develops a mathematical and computational fluid dynamics (CFD) model of an IM autoinjector by investigating the effects of viscosity, needle length, needle diameter, and medication volume on the injection process.
View Article and Find Full Text PDFAptamers as target-specific recognition elements in drug delivery.
Adv Drug Deliv Rev
September 2025
Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Molecular, Cellular, and Developmental Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Chemistry, CUNY Gradua
Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this context, nucleic acid aptamers-short, single-stranded DNA or RNA oligonucleotides capable of binding specific targets with high affinity-have emerged as promising tools for precision drug delivery and therapy. Aptamers can be selected against whole, living cells using SELEX and chemically modified for diverse applications.
View Article and Find Full Text PDFEnteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade.
Int J Pharm
September 2025
Department of Pharmaceutical Sciences, Via del Liceo 1, 06123 Perugia, Italy. Electronic address:
Indole-3-carboxaldehyde (I3A), a microbial tryptophan metabolite, exhibits significant immunomodulatory activity at the host-microbial interface. However, its rapid transformation into metabolites like indole-3-carboxylic acid (I3CA) raises questions about their therapeutic potential. This study aimed to evaluate the pharmacological contributions of I3CA through the development of a proper delivery strategy.
View Article and Find Full Text PDF