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Article Abstract
To link IFNγ-secretion levels of epitope-specific T-cells with their TCRαβ, we coated nanovials with pHLA-I to capture and activate epitope-specific T-cells and their secreted IFNγ, followed by index-sorting and TCRαβ sequencing. We demonstrate that nanovials are a promising tool to link single epitope-specific TCRαβ clonotypes to the cell's functional properties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099177 | PMC |
| http://dx.doi.org/10.1002/eji.202451666 | DOI Listing |
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