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Article Abstract
A spiroannulation reaction of β-ketothioamides with aromatic β-bromoenals and aromatic α-bromoenals via selective -Michael addition and -Michael addition-triggered cascade reactions has been developed. This protocol provides a novel and rapid approach for the synthesis of substituted spirothiopyran and spirothiophene derivatives under mild conditions with moderate to good yields and a broad substrate scope.
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| http://dx.doi.org/10.1021/acs.joc.4c01668 | DOI Listing |
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