Design, Synthesis, and Biological Evaluation of α β Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold.

A cyclic peptide role model was used for the design and synthesis of a new class of biologically active and α -selective integrin antagonists (e.g. 1) based on β-D-mannose. These carbohydrate-based peptidomimetics were synthesized to include the functional groups of their cyclic peptide precursors without the redundant amide backbone.