Synthesis of Quinoline-Based Rh-Sb Complexes: Inhibition of Halide Transfer to Access a Rh→Sb Z‑Type Interaction.

We report the synthesis of Rh-Sb complexes using high valent Sb ligands, QSbCl (, Q = 8-quinolinyl) and QSbF (), from the low valent Rh precursor [(CO)Rh-(μ-Cl)] to afford the complexes [(κ-QSbCl)-Rh-(CO)-Cl]-[(CO)RhCl] () and (κ-QSbF)-Rh-(CO)Cl (), respectively. The reaction of with [(CO)Rh-(μ-Cl)] results in the transfer of chloride from Sb to Rh to give the ion pair with a Rh-Sb bond for the cation that, according to computational analysis, has some covalent character. Replacing Sb-Cl with Sb-F bonds (, compound ) inhibited halide transfer and allowed formation of with a Rh→Sb interaction that has more Z-type character than the Rh-Sb bond for complex .

Covalent Bonding Between Ir and High-Oxidation State Sb Constrained by Quinoline Scaffolds.

From the reaction of a high-valent Sb(V) proligand with a low-valent Ir(I) precursor in acetonitrile, a bimetallic Sb-Ir complex was isolated in which one of the quinoline groups inverted such that it is -coordinated to Sb and -coordinated to Ir. The new Sb-Ir complex has a unique structure containing the shortest reported Sb-Ir bond (2.51502(18) Å).

Correction: Derivation and validation of an algorithm to predict transitions from community to residential long-term care among persons with dementia-A retrospective cohort study.

[This corrects the article DOI: 10.1371/journal.pdig.

Physician Billing in Long-Term Care Homes and the Association With the Prescribing of End-of-Life Symptom Management Medications: A Population-Based Retrospective Cohort Study.

Objectives: Medications are often needed to manage distressing end-of-life symptoms (eg, pain, agitation, dyspnea). We evaluated whether physician billing in long-term care (LTC) was associated with LTC residents' receipt of an end-of-life symptom management medication prescription.

Design: Retrospective cohort study using administrative health data.

Advancing the Care Experience for Patients Receiving Palliative Care as They Transition From Hospital to Home (ACEPATH): Phase 2 of Codesigning an Intervention to Improve Hospital-to-Home Transitions for Patients and Family Caregivers.

Background: Although many people nearing the end of life wish to die at home, many patients experience re-hospitalisation and hospital death. No end-of-life hospital-to-home interventions have been developed with patients and caregivers, and none have been tested in Canada. Through an iterative, participatory design approach, we codesigned an intervention in partnership with potential users of the final intervention: patients, family caregivers (FCs) and healthcare providers (HCPs).

Unpaid Caregiver Characteristics Associated With Retirement From the Labor Force: A Matched Case-Control Study Using CLSA Data.

Objective: To examine the caregiving factors, sociodemographic characteristics, and self-reported health of caregivers who retired from the labor force to provide full-time, unpaid care to their care recipient.

Design: Matched case-control study.

Setting And Participants: Caregiver respondents from the Canadian Longitudinal Study on Aging baseline (2011-2015), follow-up 1 (2015-2018), and follow-up 2 (2018-2021) cycles.

Associations between patient characteristics and delayed acute care discharge post-hip fracture surgery: a cohort study using linked health administrative data in Ontario, Canada.

Background: Older patients frequently experience delays in discharge post-hip fracture surgery. Our study aimed to describe the sociodemographic and clinical characteristics of patients who had a surgical repair for a hip fracture and to examine the associations between these characteristics and delayed discharge (> 6 days post-surgery) for frail vs. non frail patients.

Variations in End-of-Life Symptom Management Medication Prescribing Among Home Care Recipients in Ontario, Canada.

Context: Nearing the end of life (EOL), a variety of medications can be prescribed for symptom management during the dying process.

Objectives: To describe the prescribing of subcutaneous symptom management medications during the last six weeks of life among home care recipients in Ontario, Canada, and to assess the association of prescribing medications with EOL outcomes.

Methods: This retrospective cohort study included individuals in Ontario who died between January 1, 2017, and March 17, 2020, aged 66-105 at death and who received publicly-funded home care at least one month prior to death.

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource.

Common forms of Alzheimer's disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 donors: the IPMAR Resource (iPSC Platform to Model Alzheimer's Disease Risk). Donors were selected from a large UK cohort of 6,000+ research-diagnosed early or late-onset AD cases and elderly cognitively healthy controls, many of whom have lived through the age of risk for disease development (>85 years).

Comparing Intramedullary Nails versus Dynamic Hip Screws in the Treatment of Intertrochanteric Hip Fractures on Post-operative Rehabilitation Outcomes - A Systematic Review and Meta-Analysis.

Objective: We conducted a systematic review and meta-analysis to compare post-operative rehabilitation outcomes between two common treatments in patients who have suffered an intertrochanteric hip fracture: intramedullary nails vs dynamic hip screws.

Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science up to August 10, 2022. The inclusion criteria were defined as Population: adults (>18 years old); Interventions/Comparators: intramedullary nails and dynamic hip screws; Outcomes: function, quality of life and survival; and Study type: randomized controlled trials and non-randomized studies.

Health Care Use, Care Settings, and Location of Death for People With Schizophrenia in Long-Term Care.

Objective: To determine if health care settings in the last year of life and location of death differ between long-term care (LTC) residents with and without schizophrenia.

Design: A retrospective cohort study using health administrative data.

Setting And Participants: All adults who died in Ontario between January 1, 2010, and December 31, 2019, who were living in LTC homes 1 year before death, and who died of natural causes.

Patterns of Health Care Delivery Among Adults With Heart Failure in the Last Year of Life: A Retrospective Population-Based Study.

Background: People with heart failure (HF) are treated by multiple physician specialties as they approach the end of life (EOL). Patterns of physician involvement and health outcomes are not well understood. Elucidation of care patterns for this population may identify opportunities to minimize fragmentation and improve EOL continuity.

Why men who have sex with men in New Zealand intend to donate or not donate blood.

Background And Objectives: As blood donor deferral policies in many countries transition from blanket time-based approaches towards individualized risk-based approaches, blood services need to understand whether and why men who have sex with men (MSM) intend to donate blood. Such knowledge can help blood services develop communication strategies with a population they have historically excluded. We examined why MSM in New Zealand (NZ) intended or not to donate blood.

Long-Term Care Ownership and Operator Factors in Probable Delirium: A Population-Based Study from Ontario, Canada.

Objectives: To evaluate the association between long-term care (LTC) home ownership models and operator characteristics and the prevalence of probable delirium.

Design: Cross-sectional study using provincial health administrative data.

Setting And Participants: All LTC residents aged 65-105 years in Ontario, Canada, who underwent assessment via the Resident Assessment Instrument-Minimum Data Set, version 2.

Cognitive and Functional Decline Among Long-Term Care Residents.

Importance: Care decisions for long-term care (LTC) residents should be frailty-informed to maximize well-being and avoid burdensome treatments that do not align with patient wishes.

Objective: To investigate the incidence and time spent living with severe impairment among LTC residents to help inform person-centered decision-making.

Design, Setting, And Participants: This retrospective cohort study was conducted among a population-based cohort of incident admissions to LTC facilities between April 1, 2013, and March 31, 2018, determined using administrative health data in Ontario, Canada.

Risk of Dementia in Individuals With Emergency Department Visits or Hospitalizations Due to Cannabis.

Importance: Cannabis use is associated with short-term memory impairment and long-term changes in brain structure; however, little is known about whether disordered cannabis use is associated with an increased risk of a dementia diagnosis.

Objective: To investigate the association between emergency department visits or hospitalizations (acute care encounters) due to cannabis and future dementia diagnosis.

Design, Setting, And Participants: Population-based, retrospective, matched cohort study using health administrative data from Ontario, Canada, between 2008 and 2021 (with follow-up until 2022) including all individuals aged 45 to 105 years living in Ontario who were eligible and did not have a diagnosis of dementia at cohort entry (2 620 083 individuals excluded).

Hospital-based specialist palliative care involvement before and during the COVID-19 pandemic: secondary analysis of a regional retrospective decedent cohort study in Ottawa, Canada.

Objectives: To determine the occurrence and clinicodemographic associations of hospital-based specialist palliative care (SPC) referral before and during the COVID-19 pandemic, timing of completed SPC consultation and comparative prevalence of 'no cardiopulmonary resuscitation (CPR)' orders, and end-of-life medication use, according to SPC involvement.

Design: Cross-sectional secondary analysis of a retrospective cohort study with a pre-pandemic (November 2019 to February 2020) group (Pre-COVID, n=170) and two intra-pandemic (March to August 2020) groups, one without (COVID-ve, n=170) and one with COVID-19 infection (COVID+ve, n=85). In the cohort study, Pre-COVID and COVID-ve group decedents were matched 2:1 on age, sex and care service (internal medicine/intensive care unit (ICU)) at death with COVID+ve decedents.

Mechanistic Studies of Alkyl Chloride Acetoxylation by Pt-Sb Complexes.

The bis-acetate complexes (SbQ)Pt(OAc) () and (SbQPh)Pt(OAc) () (Q = 8-quinolinyl) were used to study C-Cl acetoxylation of 1,2-dichloroethane (DCE) to generate 2-chloroethyl acetate and the complexes (SbQ)PtCl () and (SbQPh)PtCl (), respectively. The first acetoxylation step produced the intermediates (SbQ)Pt(Cl)(OAc) () and (SbQPh)Pt(Cl)(OAc) (). The reaction was studied using pseudo first order kinetics (excess DCE) in order to compare the rates of reaction of and , which revealed that = 2.

Polymer Binder Blends Stabilize Alkaline Hydrogen Evolution by Heterogenized Molecular Phen-Based Cobalt Electrocatalysts through Coordination and Environmental Control.

With the increase in greenhouse gas emissions and their detrimental effect on the environment, there is a push to develop a renewable way to produce H, a fuel source that has nonharmful byproducts, unlike traditional methods of energy production. Alkaline water electrolysis has seen increasing focus as a viable way to produce H, but efficient and stable electrocatalysts are required to facilitate this process. Here, a heterogenized Co(II) phenanthroline-based complex for the production of H from alkaline water is disclosed.

Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects.

Regeneration after peripheral nerve injury is often insufficient for functional recovery. Postoperative electrical stimulation (PES) following injury and repair significantly improves clinical outcomes; recently, conditioning electrical stimulation (CES), delivered before nerve injury, has been introduced as a candidate for clinical translation. PES accelerates the crossing of regenerating axons across the injury site, whereas CES accelerates the intrinsic rate of axonal regeneration; thus, it is likely that their mechanisms are distinct.

Variations in Prescribing Rates of End-of-Life Medications Among Long-Term Care Residents in Alberta Compared with Ontario-a Retrospective Cohort Study.

Background: Prescribing rates for subcutaneous medications may be an indicator of quality of end-of-life care in long-term care (LTC). It is not known if this system level measure is valid across jurisdictions. We compared prescribing rates of medications used for end-of-life symptom relief among LTC residents in Alberta and Ontario.

Laboratory Test Use and Values in the Last Year of Life-a Matched Cohort Design.

Background: As individuals approach death, they experience declines in their cognitive, physical, motor, sensory, physiologic, and psychosocial functions. In this exploratory study we examined individuals' physiologic changes in the last year of life by examining laboratory tests commonly used in clinical practice.

Methods: Using health administrative datasets, we conducted an observational matched cohort study to assess laboratory test use and values over a decedent's last 12 months and a matched observation window for non-decedents.

Factors Influencing Initial Rehabilitation Type after Hip Fracture Surgery: A Retrospective Cohort Study.

Objective: To describe and compare the factors that impact initial rehabilitation type after hip fracture surgery.

Design: Retrospective population-based cohort study.

Setting And Participants: People aged between 50 and 105 with a hip fracture who had a surgical repair in Ontario, Canada, between January 1, 2015, and December 31, 2021.

Use of Feeding Tubes Among Hospitalized Older Adults With Dementia.

Importance: Although dementia is a contraindication for feeding tube placement, guidelines recommending against its use are inconsistently followed, and factors associated with its use are unclear.

Objective: To describe the incidence of feeding tube placement among hospitalized older adults (aged ≥65 years) with dementia and their health outcomes during and after hospitalization and to identify factors associated with placement of feeding tubes (ie, gastrostomy, gastrostomy-jejunostomy, and jejunostomy tubes).

Design, Setting, And Participants: This population-based retrospective cohort study was conducted using a linked database in Ontario, Canada.