Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab.

Introduction: Consistent predictive performance across racial and ethnic groups is essential to the use of plasma biomarkers as screening tools in preclinical Alzheimer's disease trials.

Methods: Logistic regression examined racial and ethnic group differences in plasma eligibility using an algorithm that included Phosphorylated tau217 to non-phosphorylated tau217 ratio, amyloid beta 42/40, age, and apolipoprotein E to predict > 18 Centiloids on amyloid imaging in cognitively unimpaired individuals.

Results: Among 6437 participants screened, with non-Hispanic (NH) White as the reference group, odds ratios of plasma ineligibility were 2.

Unveiling cystic echinococcosis: Seroprevalence trends and risk dynamics in Northern India.

Background: Cystic echinococcosis, a zoonotic parasitic disease, is caused by the larvae of Echinococcus granulosus. It is a global public health problem with significant disease burden in India.

Objective: To determine the prevalence and epidemiological characteristics of cystic echinococcosis (CE) in the study population, thereby providing insights into its burden, seasonal trends, and geographical distribution to inform effective control and prevention strategies.

Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study.

Background: Central line-associated bloodstream infections (CLABSIs) are preventable health-care-associated infections (HAIs) that cause considerable morbidity and mortality. Understanding the epidemiology of CLABSIs through large, quality-assured, hospital-based datasets could help to enable development of preventive protocols suited to specific health-care systems. We aimed to describe the profile of CLABSIs in intensive care units (ICUs) at tertiary care centres in India.

Carbapenem-Resistant Enterobacterales in Indian ICU Patients: Molecular Insights, Risk Factors, and Clinical Impact.

Carbapenem-resistant Enterobacterales (CRE) pose a critical threat in intensive care units (ICUs) due to rapid transmission potential and limited treatment options. The study aimed to determine the incidence of intestinal CRE colonization among ICU patients, characterize the isolates phenotypically and genotypically and identify associated risk factors. This cross-sectional study was conducted in a tertiary care hospital in North India and included 236 ICU patients.

A hospital-based observational study on HIV-TB co-infection.

Human immunodeficiency virus (HIV) is the major cause of failure to reach targets of tuberculosis (TB) control in settings with high HIV loads. TB, on the other hand, enhances the progression of HIV infection to AIDS. This study was done to understand the epidemiological and clinical profile of HIV-TB co-infected patients and to study the impact of TB on the recovery of CD4 counts.