Integration of Genome and Epigenetic Testing in the Diagnostic Evaluation of Developmental Delay: Differentiating Börjeson-Forssman-Lehmann (BFLS) and White-Kernohan (WHIKERS) Syndromes.

: More than 1500 genes are associated with developmental delay and intellectual disability, with variants in many of these genes contributing to a shared phenotype. The discovery of variants of uncertain significance (VUS) found in these genes during genetic testing can lead to ambiguity and further delay in diagnosis and medical management. Phenotyping, additional genetic testing, and functional studies can all add valuable information to help reclassify these variants.

Conformational Frustration at the Protein-Glycan Interface of a Nonmitogenic Anti-HIV Lectin Results in Altered Quaternary Structure.

Lectins are carbohydrate-binding proteins that have enormous therapeutic value because of their potent antiviral activity. However, the design of lectins for targeted intervention is marred by our poor understanding of protein-glycan recognition. Here, we focus on the mannose-specific lectin horcolin, which is nonmitogenic and shows dose-dependent inhibition of HIV infection.

Chitosan-based formulations for therapeutic applications. A recent overview.

Chitosan is a cationic natural polymer composed of glucosamine and N-acetylglucosamine residues that are held together by a glycosidic bond. Chitosan has many excellent properties, including physicochemical properties, i.e.

Validation of the Texas School Physical Activity and Nutrition (SPAN) Dietary Index Against the Healthy Eating Index Among Elementary-Aged Students.

: Assess the accuracy of the Texas School Physical Activity and Nutrition (SPAN) survey's diet quality index against the 24 h recall-based Healthy Eating Index (HEI-2020). : Fifty-one rising third and fourth graders (mean age 9.5 yrs.