Publications by authors named "Soichiro Nakajima"
Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer.
Target Oncol
January 2024
Background: The TRUSTY study evaluated the efficacy of second-line trifluridine/tipiracil (FTD/TPI) plus bevacizumab in metastatic colorectal cancer (mCRC).
Objective: This exploratory biomarker analysis of TRUSTY investigated the relationship between baseline plasma concentrations of angiogenesis-related factors and cell-free DNA (cfDNA), and the efficacy of FTD/TPI plus bevacizumab in patients with mCRC.
Patients And Methods: The disease control rate (DCR) and progression-free survival (PFS) were compared between baseline plasma samples of patients with high and low plasma concentrations (based on the median value) of angiogenesis-related factors.
Study Protocol for the Pleiotropic Effects of Sodium-Glucose Cotransporter 2 Inhibitor on Organ-Specific Sympathetic Nerve Activity and Insulin Sensitivity in Participants with Type 2 Diabetes.
Diabetes Ther
January 2024
Article Synopsis
- The study investigates how two different types of diabetes medications, SGLT2 inhibitors and sulfonylureas, affect systemic sympathetic nerve activity (SNA) in patients with type 2 diabetes who also have atherosclerosis risk factors.
- It is a 24-week ongoing trial at Kanazawa University Hospital, comparing the effects of luseogliflozin (2.5 mg) and glimepiride (0.5 mg) on muscle SNA and other insulin sensitivity metrics, with a target sample size of 40 participants.
- The trial started recruiting in April 2020 and is expected to conclude by March 2025, having received approval from the relevant ethical review board and is registered
A film-stack reaction field with a micropillar array using a motor stirrer was developed for the high sensitivity and rapid enzyme-linked immunosorbent assay (ELISA) reaction. The effects of the incubation time of a protein (30 s, 5 min, and 10 min) on the fluorescence intensity in ELISAs were investigated using a reaction field with different micropillar array dimensions (5-µm, 10-µm and 50-µm gaps between the micropillars). The difference in fluorescence intensity between the well with the reaction field of 50-µm gap for the incubation time of 30 s and the well without the reaction field with for incubation time of 10 min was 6%.
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