Approaches to address common barriers to colorectal cancer screening in rural communities of the CDC's colorectal cancer control program.

Introduction: We identified potential approaches to address barriers to colorectal cancer (CRC) screening in rural communities of award recipients from the Centers for Disease Control and Prevention's Colorectal Cancer Control Program (CRCCP).

Methods: Nine program managers and directors discussed approaches to address barriers to CRC screening. The programs served areas with rural communities and tribal reservations.

Promising approaches to support sustained colorectal cancer screening promotion strategies in primary care clinics.

Background: The Colorectal Cancer Control Program (CRCCP) funds recipients to partner with primary care clinics to adopt and sustain evidence-based interventions (EBIs) that increase CRC screening. This qualitative study explored how CRCCP recipients support their clinic partners to sustain EBI implementation.

Materials And Methods: Two waves of data collection - including 27 key informant interviews and 4 validation focus groups with CRCCP recipients - explored recipients' preparation for partnering with potential clinics and supporting EBI implementation and sustainment.

Structures of two LarA-like nickel-pincer nucleotide cofactor-utilizing enzymes with a single catalytic histidine residue.

The nickel pincer nucleotide (NPN) cofactor catalyzes the racemization/epimerization of α-hydroxy acids in enzymes of the LarA family. The established proton-coupled hydride transfer mechanism requires two catalytic histidine residues that alternately act as general acids and general bases. Notably, however, a fraction of LarA homologs (LarAHs) lack one of the active site histidine residues, replacing it with an asparaginyl side chain that cannot participate in acid/base catalysis.

Contribution of different frass fertilizer products on enhanced growth, yield and nutrient quality of Broccoli [].

Vegetables are crucial for food security and income, but in developing countries their production is hindered by low soil fertility. Although the insect frass fertilizer is a potential solution, its use is constrained by limited product choices. Unlike conventional fertilizers, which are available in different forms, the insect frass fertilizer is mostly available in solid form.

Integrated Model of Cancer Control for Early Detection and Treatment in Adolescents and Young Adults Living With HIV: Protocol for a Cluster Randomized Controlled Trial.

Background: Zambia has one of the highest prevalence rates of HIV among adolescents and young adults (AYA) living with HIV in sub-Saharan Africa, which accounts for half of all new HIV cases as of 2023. Compared to their peers who are not living with HIV, AYA living with HIV are more likely to develop cancer. The most frequently diagnosed cancers among AYA living with HIV in Zambia are cervical cancer, Kaposi sarcoma, and non-Hodgkin lymphoma.