A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis.

Hematopoietic multipotent progenitors (MPPs) regulate blood cell production to meet the evolving demands of an organism. Adult human MPPs remain ill defined, whereas mouse MPPs are well characterized, with distinct immunophenotypes and lineage potencies. Using multi-omic single-cell analyses and functional assays, we identified distinct human MPPs within Lin-CD34+CD38dim/lo adult bone marrow with unique biomolecular and functional properties.

Exploring the impact of note taking methods on cognitive function among university students.

Background: Taking notes during lectures plays a vital role in enhancing learning outcomes. With technological advancements, digital note-taking has gained popularity among university students in recent years due to its convenience, ease of storage, sharing, and searching. Different versions of digital note-taking have been introduced, including the use of styluses on tablets, which offer a blend of traditional handwriting and digital advantages.

Clinical study to evaluate the efficacy and safety of an herbal toothpaste in reducing gingivitis in a diabetic population.

Purpose: To assess the efficacy and safety of Glister multi-action toothpaste Herbals (GHT) on gingivitis in diabetic subjects.

Methods: A total of 72 diabetic subjects were enrolled and 61 subjects completed the open label single arm clinical study for a period of 30 days. Subjects were evaluated on Day 10 (visit 3), Day 20 (visit 4), and Day 30 (visit 5) for reduction in gingivitis, plaque, gingival bleeding, pocket depth, S.