Characteristics of Transfusion and Association With Oncologic Outcomes in Hepatoblastoma Resection.

Introduction: Children with hepatoblastoma (HB) and other solid tumors frequently undergo intraoperative blood transfusion (IBT) with unknown impact on oncologic outcomes and scant data to guide transfusion in this population. This study tested the hypothesis that IBT is associated with poorer survival in children with HB.

Methods: A multicenter retrospective observational study of patients aged <18 years with HB who underwent primary tumor resection, including liver transplantation, from 2010 to 2019 was performed at 19 institutions.

Influence of Pre-Existing Pain on the Body's Response to External Pain Stimuli: Experimental Study.

Background: Accurately assessing pain severity is essential for effective pain treatment and desirable patient outcomes. In clinical settings, pain intensity assessment relies on self-reporting methods, which are subjective to individuals and impractical for noncommunicative or critically ill patients. Previous studies have attempted to measure pain objectively using physiological responses to an external pain stimulus, assuming that the participant is free of internal body pain.

The bactericidal and thrombotic potentials of extracellular TRAP-enclosed neutrophil vesicles released in response to Staphylococcus aureus at high glucose concentration.

The ejection of neutrophil extracellular traps (NETs) is one of the characteristic features of neutrophils. Rapid release of NET-containing extracellular vesicles (NET-EVs) to the extracellular space has been reported as a novel NET release mechanism in response to Staphylococcus aureus. An increased number of these NET-EVs are released from neutrophils maintained at high-glucose conditions.

Evaluating the Role of Faecal Calprotectin in Older Adults.

Background Faecal calprotectin (FC) is a marker of gastrointestinal (GI) inflammation widely used in primary care to identify patients requiring referral for endoscopic assessment. Most guidelines advise against its use in older adults due to higher rates of colorectal cancer. Many studies include only younger adults, despite FC continuing to be used in older adults.