Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies.

Background And Objectives: Neuroimaging findings in immune effector cell-associated neurotoxicity syndrome (ICANS) have not been systematically described. We created the chimeric antigen receptor (CAR) T-cell Neurotoxicity Imaging Virtual Archive Library (CARNIVAL), a centralized imaging database for children and young adults receiving CAR T-cell therapy. Objectives of this study were to (1) characterize neuroimaging findings associated with ICANS and (2) determine whether specific ICANS-related neuroimaging findings are associated with individual neurologic symptoms.

Patients' Acceptance and Intentions on Using Artificial Intelligence in Dental Diagnosis: Insights From Unified Theory of Acceptance and Use of Technology 2 Model.

Introduction And Aims: Artificial intelligence (AI) is transforming dental care by enhancing diagnostic accuracy, efficiency, and patient experience. This study aimed to assess dental patients' acceptance, perceptions, and concerns regarding AI-powered diagnosis using the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) framework through structural equation modelling (SEM).

Methods: A cross-sectional study was conducted among dental patients at King Saud University Dental Hospital, Riyadh.

Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2.

Unlabelled: There remains an unmet clinical need for improved treatment strategies in Acute Myeloid Leukemia (AML). Although radiopharmaceutical therapies targeting non-cancer-selective antigens have shown promise in AML, their clinical utility is often limited by prolonged bone marrow suppression. Using a unique proteomics-based strategy, we recently identified the active conformation of integrin-β2 (aITGB2) as a novel, tumor-selective target for AML.

Cardiac function and extracellular matrix morphology are altered by chronic high fat diet in Drosophila larvae.

Cardiovascular disease is characterized by aberrant and excessive extracellular matrix (ECM) remodelling, termed fibrosis. Fibrotic remodelling is typically triggered by inflammation, which occurs systemically in obesity. Despite the contribution of fibrosis to adverse clinical outcomes and disease progression, there are no available treatments for this condition.